ArticleJournal of bacteriology2013
RfaH promotes the ability of the avian pathogenic Escherichia coli O2 strain E058 to cause avian colibacillosis.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Chicken cathelicidin-3 protected mice from avian pathogenic Escherichia coli infection mediated by triggering chemokine CCL3 pathway.Veterinary research · 2026Article
- High-risk clonal groups of avian pathogenicVirulence · 2025Article
- Phenotypic and genotypic characterization of biofilm-producing avian pathogenic Escherichia coli (APEC) isolates from Algerian poultry: associations between antimicrobial resistance and virulence genes.Veterinary research communications · 2025Article
- TssL2 of T6SS2 is required for mobility, biofilm formation, wrinkly phenotype formation, and virulence of Vibrio parahaemolyticus SH112.Applied microbiology and biotechnology · 2024Article
- Article
- Putative transcription antiterminator RfaH contributes to Erwinia amylovora virulence.Molecular plant pathology · 2022Article
- Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment.mSphere · 2022Article
- Avian PathogenicPathogens (Basel, Switzerland) · 2021Review
- Transcriptional Regulator YqeI, Locating at ETT2 Locus, Affects the Pathogenicity of Avian PathogenicAnimals : an open access journal from MDPI · 2020Article
- Novel small molecules affecting cell membrane as potential therapeutics for avian pathogenic Escherichia coli.Scientific reports · 2018Article
- Novel small molecule modulators of quorum sensing in avian pathogenic Escherichia coli (APEC).Virulence · 2018Article
- Article
- IbeR facilitates stress-resistance, invasion and pathogenicity of avian pathogenic Escherichia coli.PloS one · 2015Article
- DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli.Frontiers in microbiology · 2014Article
- The transfer-messenger RNA-small protein B system plays a role in avian pathogenic Escherichia coli pathogenicity.Journal of bacteriology · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian pathogenic Escherichia coli (APEC) infection causes avian colibacillosis, which refers to any localized or systemic infection, such as acute fatal septicemia or subacute pericarditis and airsacculitis. The RfaH transcriptional regulator in E. coli is known to regulate a number of phenotypic traits. The direct effect of RfaH on the virulence of APEC has not been investigated yet. Our results showed that the inactivation of rfaH significantly decreased the virulence of APEC E058. The attenuation was assessed by in vivo and in vitro assays, including chicken infection assays, an ingestion and intracellular survival assay, and a bactericidal assay with serum complement. The virulence phenotype was restored to resemble that of the wild type by complementation of the rfaH gene in trans. The results of the quantitative real-time reverse transcription-PCR (qRT-PCR) analysis and animal system infection experiments indicated that the deletion of rfaH correlated with decreased virulence of the APEC E058 strain.
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