ArticleSurgery today2014
New hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials.
Article in Surgery today, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- A Developmental Roadmap Toward Abdominal Adhesions Prevention Technologies.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Review
- A Scoping Review of Animal Models for Development of Abdominal Adhesion Prevention Strategies.The Journal of surgical research · 2024Article
- Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Regeneration of peritoneal mesothelial cells after placement of hyaluronate carboxymethyl-cellulose (SeprafilmSurgery today · 2017Article
- A Nomogram to Predict Hypertrophy of Liver Segments 2 and 3 After Right Portal Vein Embolization.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Application of hyaluronic acid/sodium alginate-based microparticles to prevent tissue adhesion in a rabbit model.Surgery today · 2016Article
- Extensive Adhesions in Living Donor Liver Transplantation: A Retrospective Analysis.World journal of surgery · 2016Article
- Evaluation of the Effectiveness of Peritoneal Adhesion Prevention Devices in a Rat Model.International journal of medical sciences · 2016Article
- An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation.Scientific reports · 2015Article
- Drug development for intraperitoneal chemotherapy against peritoneal carcinomatosis from gastrointestinal cancer.Surgery today · 2014Review
- Evaluation of the xenobiotic reaction against hyaluronate-based bioresorbable membrane in the abdominal cavity.Progress in biomaterialsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRepeated hepatic resections are not uncommon during the surgical management of liver tumors. Postoperative adhesions induced by hepatectomies can have a significant negative impact on subsequent surgeries. We recently developed a new hepatectomy-induced postoperative adhesion animal model to evaluate the anti-adhesion efficacy of commercially available sheet materials (Seprafilm(®) and Interceed(®)) and the recently reported hyaluronan-based in situ cross-linkable hydrogels.
methodsThe median lobe (ML) and the left lateral lobe (LLL) of the liver (approximately 70 % of the total liver) of 43 male Sprague-Dawley rats were resected based on the classical procedure; anti-adhesion materials were then applied. A relaparotomy was performed 1 week later to evaluate the adhesions and histopathological findings.
resultsThe rats without the application of anti-adhesion materials (n = 14) showed the most severe adhesions (grade 3) between the cut surface of the liver and the small bowel or omentum. All the barrier materials produced slight anti-adhesion effects. Adhesions between the liver surface and the diaphragm and adhesions around the hepatic hilum were less severe, but were not remarkably reduced, by the anti-adhesion materials.
conclusionWe successfully established a new hepatectomy-induced animal adhesion model, which may be useful for the development of new anti-adhesion materials.
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