ArticleFrontiers in neural circuits2013
In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
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- Rich dynamics and functional organization on topographically designed neuronal networksiScience · 2022Article
- Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering.Brain sciences · 2022Review
- Organic electrochemical neurons and synapses with ion mediated spiking.Nature communications · 2022Article
- Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.Micromachines · 2021Review
- Plasticity and Adaptation in Neuromorphic Biohybrid Systems.iScience · 2020Review
- A biohybrid synapse with neurotransmitter-mediated plasticity.Nature materials · 2020Article
- Article
- Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain.Frontiers in neurology · 2019Review
- Optimized Real-Time Biomimetic Neural Network on FPGA for Bio-hybridization.Frontiers in neuroscience · 2019Article
- Modeling driver cells in developing neuronal networks.PLoS computational biology · 2018Article
- Astrocytes restore connectivity and synchronization in dysfunctional cerebellar networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording and Sub-Millisecond Processing of Biosignals.Sensors (Basel, Switzerland) · 2018Article
- Editorial: Closed-Loop Systems for Next-Generation Neuroprostheses.Frontiers in neuroscience · 2018Article
- Fast wide-volume functional imaging of engineered in vitro brain tissues.Scientific reports · 2017Article
- Simultaneous high-speed imaging and optogenetic inhibition in the intact mouse brain.Scientific reports · 2017Article
- An FPGA Platform for Real-Time Simulation of Spiking Neuronal Networks.Frontiers in neuroscience · 2017Article
- Coupling Resistive Switching Devices with Neurons: State of the Art and Perspectives.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-machine interfaces (BMI) were born to control "actions from thoughts" in order to recover motor capability of patients with impaired functional connectivity between the central and peripheral nervous system. The final goal of our studies is the development of a new proof-of-concept BMI-a neuromorphic chip for brain repair-to reproduce the functional organization of a damaged part of the central nervous system. To reach this ambitious goal, we implemented a multidisciplinary "bottom-up" approach in which in vitro networks are the paradigm for the development of an in silico model to be incorporated into a neuromorphic device. In this paper we present the overall strategy and focus on the different building blocks of our studies: (i) the experimental characterization and modeling of "finite size networks" which represent the smallest and most general self-organized circuits capable of generating spontaneous collective dynamics; (ii) the induction of lesions in neuronal networks and the whole brain preparation with special attention on the impact on the functional organization of the circuits; (iii) the first production of a neuromorphic chip able to implement a real-time model of neuronal networks. A dynamical characterization of the finite size circuits with single cell resolution is provided. A neural network model based on Izhikevich neurons was able to replicate the experimental observations. Changes in the dynamics of the neuronal circuits induced by optical and ischemic lesions are presented respectively for in vitro neuronal networks and for a whole brain preparation. Finally the implementation of a neuromorphic chip reproducing the network dynamics in quasi-real time (10 ns precision) is presented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.