ArticleRheumatology international2014
Prolongation of heart rate-corrected QT interval is a predictor of cardiac autonomic dysfunction in patients with systemic lupus erythematosus.
Article in Rheumatology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Circulating anti-Ro/Sjögren's syndrome-related antigen A antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis.European heart journal open · 2026Article
- Should Physicians Be Aware of Rhythm Disturbances in Adults with Systemic Autoimmune Diseases and Anti-Ro52 Antibodies? A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases.International journal of molecular sciences · 2022Review
- Hydroxychloroquine use is not associated with QTc length in a large cohort of SLE and RA patients.Arthritis research & therapy · 2021Article
- Hydroxychloroquine Use Is Not Associated With QTc Length in a Large Cohort of SLE and RA Patients.Research square · 2021Article
- Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome.Frontiers in medicine · 2021Review
- Pupillary autonomic dysfunction in patients with ANCA-associated vasculitis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Article
- Prolonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseases.Rheumatology international · 2017Article
- Assessment of autonomic function in a cohort of patients with ANCA-associated vasculitis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Article
- Long QT Syndrome: An Emerging Role for Inflammation and Immunity.Frontiers in cardiovascular medicine · 2015Review
- Exercise Profile and Diastolic Functions Measured via Tissue Doppler Imaging of Fibromyalgia Patients.Journal of clinical medicine research · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
Heart rate-corrected QT interval duration (QTc) has been shown to be related to cardiac autonomic dysfunction in patients with diabetes mellitus, although this association has not been previously described in patients with systemic lupus erythematosus (SLE). We retrospectively reviewed the medical records of 91 SLE patients and 144 non-SLE connective tissue disease patients visiting our clinic from November 2010 to April 2011. We compared ambulatory heart rate identified by pulse measured by automated machine in an outpatient waiting area versus resting heart rate identified on prior screening electrocardiogram. Heart rate differences were analyzed in relation to QTc interval and other characteristics. Ambulatory and resting heart rate differences were larger among SLE patients with QTc prolongation (QTc > 430 ms) than those without QTc prolongation (mean difference, 15.9 vs. 9.6, p = 0.001). In multivariate analysis, differences in heart rate were associated with QTc prolongation (OR 1.10, 95 % CI 1.01-1.21; p = 0.038), independent of age, duration of disease, immunosuppressant use, hydroxychloroquine use, diabetes mellitus, cardiac abnormality, anti-Ro/SS-A antibody positivity, or resting heart rate. Cardiac autonomic dysfunction is a common manifestation of SLE and may be related to QTc prolongation.
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