Evidence map›Paper›PMID 23503768›Full record

ArticlePediatric nephrology (Berlin, Germany)2013

Limited value of routine microalbuminuria assessment in multi-ethnic obese children.

Nalini N E Radhakishun, Mariska van Vliet, Ines A von Rosenstiel, Jos H Beijnen, Michaela Diamant

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Can childhood obesity influence later chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2019
    Review
  4. Subclinical Organ Damage in Children and Adolescents with Hypertension: Current Guidelines and Beyond.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019
    Review
  5. Article
  6. Article
  7. Non-Traditional Risk Factors of Albuminuria in the Pediatric Population: A Scoping Review.International journal of environmental research and public health · 2017
    Article
  8. Article
  9. Microalbuminuria in Children With Primary Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016
    Article
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nalini N E RadhakishunDepartment of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. Nalini.Radhakishun@slz.nl
Mariska van Vliet
Ines A von Rosenstiel
Jos H Beijnen
Michaela Diamant
Slotervaartziekenhuis · NLAmsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the prevalence of microalbuminuria and its association with cardiometabolic risk factors in a multi-ethnic cohort of overweight and obese children. CASE-DIAGNOSIS/TREATMENT: A retrospective analysis of prospectively collected data was performed using data from 408 overweight and obese children (age 3-19 years). In addition to administering an oral glucose tolerance test, we measured anthropometric variables, plasma lipid levels, alanine aminotransferase and the urinary albumin/creatinine ratio (ACR). Microalbuminuria was defined as an ACR of between 2.5 and 25 mg/mmol in boys and 3.5 and 25 mg/mmol in girls. In total, only 11 (2.7 %) of the children analyzed presented with microalbuminuria, with no differences between ethnic groups, sex or in the prevalence of hypertension compared to the children with normoalbuminuria. After adjustment for confounders, the body mass index Z-score tended to be different between the group with microalbuminuria versus that without (3.6 vs. 3.2, respectively; P = 0.054). ACR was not associated with hypertension, impaired glucose tolerance, high triglycerides or low high-density lipoprotein-cholesterol.

conclusionsIn a large multi-ethnic cohort of overweight and obese children, we found a low prevalence of microalbuminuria (11 children, 2.7 %), and in this small number of individuals, we found no association with any of the cardiometabolic risk factors assessed. Therefore, our data do not support the routine measurement of microalbuminuria in asymptomatic overweight and obese children and adolescents.

Indexed as

AdolescentAlbuminuriaBiomarkersBody Mass IndexChildChild, PreschoolChi-Square DistributionFemaleGlucose Tolerance TestHumansLinear ModelsLogistic ModelsMaleMetabolic SyndromeNetherlandsOdds RatioBiomarkers

Identifiers

PMID23503768
OpenAlexW1967569778

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.