Trial reportCancer prevention research (Philadelphia, Pa.)2013
Association of tooth loss and oral hygiene with risk of gastric adenocarcinoma.
Trial report in Cancer prevention research (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Tooth loss and infrequent brushing significantly elevate gastric cancer risk: an updated systematic review and meta-analysis with heterogeneity exploration.Frontiers in medicine · 2026Pooled it
- Gastric adenocarcinoma and periodontal disease: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2024Pooled it
- Environmental etiology of gastric cancer in Iran: a systematic review focusing on drinking water, soil, food, radiation, and geographical conditions.Environmental science and pollution research international · 2019Pooled it
- Association between Tooth Loss and Gastric Cancer: A Meta-Analysis of Observational Studies.PloS one · 2016Pooled it
- Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis.Scientific reports · 2015Pooled it
- Predictive Value of the nProfiler 1 Assay for the Efficacy of Adjuvant S-1-Based Doublet Chemotherapy in Stage III Gastric Cancer: A Post-Hoc Analysis of a Randomized Phase III Trial.Cancer research and treatment · 2025Trial
- Periodontitis prevalence and effects on postoperative complications in gastric surgery: a prospective observational study.BMC oral health · 2026Observational
- The association between poor dental health and gastric cancer risk: a nationwide cohort and sibling-controlled study.BMC medicine · 2025Article
- Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection.International dental journal · 2025Article
- Integrating Salivary Biomarkers CST4 andClinical Medicine Insights. Oncology · 2025Article
- Association Between Oral Health and Gastric Cancer in Korean Adults.The Korean journal of helicobacter and upper gastrointestinal research · 2024Article
- One-carbon metabolism biomarkers and upper gastrointestinal cancer in the Golestan Cohort Study.International journal of cancer · 2024Article
- Pretreatment periodontitis is predictive of a poorer prognosis after esophagectomy for esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Poor oral health was associated with higher risk of gastric cancer: Evidence from 1431677 participants.World journal of gastrointestinal surgery · 2024Article
- Cancer patterns in Iran: a gender-specific spatial modelling of cancer incidence during 2014-2017.BMC cancer · 2024Article
- Head and neck cancer patients show poor oral health as compared to those with other types of cancer.BMC oral health · 2023Article
- Review
- Article
- Trends in the Performance of the Korean National Cancer Screening Program for Gastric Cancer from 2007 to 2016.Cancer research and treatment · 2022Article
- Epidemiology of stomach cancer.World journal of gastroenterology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
Poor oral health and tooth loss have been proposed as possible risk factors for some chronic diseases, including gastric cancer. However, a small number of studies have tested these associations. We conducted a case-control study in Golestan Province, Iran, that enrolled 309 cases diagnosed with gastric adenocarcinoma (118 noncardia, 161 cardia, and 30 mixed-locations) and 613 sex, age, and neighborhood matched controls. Data on oral health were obtained through physical examination and questionnaire including tooth loss, the number of decayed, missing, and filled teeth, and frequency of tooth brushing. ORs and 95% confidence intervals (95% CI) were obtained using conditional logistic regression models adjusted for potential confounders. Standard one degree-of-freedom linear trend test and a multiple degree-of-freedom global test of the effect of adding oral hygiene variables to the model were also calculated. Our results showed apparent associations between tooth loss and decayed, missing, filled teeth (DMFT) score with risk of gastric cancer, overall and at each anatomic subsite. However, these associations were not monotonic and were strongly confounded by age. The results also showed that subjects who brushed their teeth less than daily were at significantly higher risk for gastric cardia adenocarcinoma ORs (95% CI) of 5.6 (1.6-19.3). We found evidence for an association between oral health and gastric cancer, but the nonmonotonic association, the relatively strong effect of confounder adjustment, and inconsistent results across studies must temper the strength of any conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.