ArticleFrontiers in cellular neuroscience2013
A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Small molecule-mediated rapid generation of functional human astrocytes: unveiling AKT1-STAT1/3 signaling in astrocyte development.Stem cell research & therapy · 2025Article
- Asteroid impact: the potential of astrocytes to modulate human neural networks within organoids.Frontiers in neuroscience · 2023Review
- Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models.Cells · 2022Review
- Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.Cells · 2021Review
- Review of Design Considerations for Brain-on-a-Chip Models.Micromachines · 2021Review
- Generation of the Human Pluripotent Stem-Cell-Derived Astrocyte Model with Forebrain Identity.Brain sciences · 2021Article
- Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.Translational psychiatry · 2019Article
- Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.Comprehensive physiology · 2019Review
- Astrocytes and microglia: Models and tools.The Journal of experimental medicine · 2019Review
- Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells.Journal of visualized experiments : JoVE · 2018Article
- Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.Stem cell reports · 2017Article
- Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.Neuron · 2017Article
- Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders.Brain pathology (Zurich, Switzerland) · 2017Article
- Role of astrocyte-synapse interactions in CNS disorders.The Journal of physiology · 2017Review
- Human astrocytes are distinct contributors to the complexity of synaptic function.Brain research bulletin · 2017Review
- Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.Genome medicine · 2016Article
- Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research.Frontiers in cellular neuroscience · 2016Review
- Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.Trends in molecular medicine · 2015Review
- Dysregulation of astrocyte extracellular signaling in Costello syndrome.Science translational medicine · 2015Article
- Tat-induced histopathological alterations mediate hippocampus-associated behavioural impairments in rats.Behavioral and brain functions : BBF · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
What roles do astrocytes play in human disease?This question remains unanswered for nearly every human neurological disorder. Yet, because of their abundance and complexity astrocytes can impact neurological function in many ways. The differentiation of human pluripotent stem cells (hPSCs) into neuronal and glial subtypes, including astrocytes, is becoming routine, thus their use as tools for modeling neurodevelopment and disease will provide one important approach to answer this question. When designing experiments, careful consideration must be given to choosing paradigms for differentiation, maturation, and functional analysis of these temporally asynchronous cellular populations in culture. In the case of astrocytes, they display heterogeneous characteristics depending upon species of origin, brain region, developmental stage, environmental factors, and disease states, all of which may render experimental results highly variable. In this review, challenges and future directions are discussed for using hPSC-derived astroglial progenitors and mature astrocytes for neurodevelopmental studies with a focus on exploring human astrocyte effects upon neuronal function. As new technologies emerge to measure the functions of astrocytes in vitro and in vivo, there is also a need for a standardized source of human astrocytes that are most relevant to the diseases of interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.