ArticleOccupational and environmental medicine2013
A case-control study of paternal occupational exposures and the risk of childhood sporadic bilateral retinoblastoma.
Article in Occupational and environmental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Parental and childhood exposures and the risk of retinoblastoma, hepatoblastoma, and germ cell, bone, and soft tissue tumors in children: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Paternal exposure to hydrocarbon solvents in the workplace and cancer risk in children and adolescents.Journal of exposure science & environmental epidemiology · 2026Article
- Spatial analysis of residential location at birth, PFAS in public water, and childhood cancers in Southern California (2000-2019).Journal of exposure science & environmental epidemiology · 2026Article
- Influence of Social and Demographic Factors on Retinoblastoma Outcomes in the United States: A Systematic Review.Cochrane evidence synthesis and methods · 2026Review
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Prenatal ambient pesticide exposure and childhood retinoblastoma.International journal of hygiene and environmental health · 2022Article
- Incidence of retinoblastoma in children and adolescents in Brazil: A population-based study.Frontiers in pediatrics · 2022Article
- Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease.Cancer reports (Hoboken, N.J.) · 2021Article
- Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children's Oncology Group.Occupational and environmental medicine · 2018Article
- Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group.American journal of ophthalmology · 2017Article
- A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma.Pediatric radiology · 2016Review
- PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors.Molecular biology reports · 2014Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe risk factors for sporadic (ie, non-familial) retinoblastoma remain largely unknown.
objectivesWe examined the relationship between paternal occupational exposures from jobs held 10 years and 1 year prior to conception and the risk of sporadic bilateral retinoblastoma in children.
methodsPaternal occupational data were obtained for 198 incident cases diagnosed with sporadic bilateral retinoblastoma from January 1998 to May 2006 and 245 referral-based controls from the case child's relatives and friends who were matched to 135 of the cases on birth year. Industrial hygienists independently assigned exposure scores for nine agents. Adjusted ORs and 95% CIs were computed using logistic regression models, using the full sample of cases and controls as well as subset of cases with matched controls only.
resultsThere was some indication of an elevated risk associated with paternal pesticide exposure in the 10 years prior to conception (OR=1.64; 95% CI 1.08 to 2.50) as well as in the year before conception (OR=2.12; 95% CI 1.25 to 3.61). However, results for pesticide exposure were inconsistent and varied by analysis approach. An increased risk was also observed for non-welding metal exposure during the 10 years prior to conception in the full (OR=1.35; 95% CI 0.86 to 2.12) and matched (OR=1.40; 95% CI 0.82 to 2.37) samples, but not in the year before conception. Exposure-response trends were observed for pesticides and non-welding metal exposures.
conclusionsOur findings suggest a potential role of paternal occupational exposures to non-welding metals and perhaps pesticides in the aetiology of childhood retinoblastoma.
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