ReviewOncogene2014
Context-specific regulation of cancer epigenomes by histone and transcription factor methylation.
Review in Oncogene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association between H3K4 methylation and cancer prognosis: A meta-analysis.Thoracic cancer · 2018Pooled it
- Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.Nature communications · 2023Article
- Targeting Smyd3 by next-generation antisense oligonucleotides suppresses liver tumor growth.iScience · 2021Article
- Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features.Journal of hepatology · 2021Article
- CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression.EBioMedicine · 2018Article
- Functional assessment of von Willebrand factor expression by cancer cells of non-endothelial origin.Oncotarget · 2017Article
- Mechanism of gene-specificity of oncogenic regulators.Cell cycle (Georgetown, Tex.) · 2016Article
- Chemical genetics approaches for selective intervention in epigenetics.Current opinion in chemical biology · 2016Review
- SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.Cell reports · 2016Article
- Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686.Oncotarget · 2016Article
- Article
- A property-based analysis of human transcription factors.BMC research notes · 2015Article
- Curcumin and dimethoxycurcumin induced epigenetic changes in leukemia cells.Pharmaceutical research · 2015Article
- Overexpression of SMYD2 contributes to malignant outcome in gastric cancer.British journal of cancer · 2015Article
- Metabolic regulation of histone post-translational modifications.ACS chemical biology · 2015Review
- Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets.Frontiers in oncology · 2015Review
- A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.Mechanisms of development · 2014Article
- Cytotoxic Potential and Metabolomic Profiling ofIntegrative cancer therapiesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Altered expression or activity of histone lysine methylases and demethylases in cancer lead to aberrant chromatin modification patterns, which contribute to uncontrolled cell proliferation via cancer-specific deregulation of gene expression programs or the induction of genome instability. Several transcription factors that regulate growth-associated genes undergo lysine methylation, expanding the repertoire of regulatory targets modulated by histone-methylating enzymes during tumorigenesis. In certain specific tumor types or specific physiological conditions, these enzymes may trigger chromatin structure and/or transcription factor activity changes that result in opposite effects on cancer initiation or progression. The mechanisms of such context-specific dual functions and those involved in the crosstalk between factor and histone modifications are subject to extensive research, which is beginning to shed light into this novel level of complexity of cancer-related epigenetic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.