ArticleHeart (British Cardiac Society)2013
Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study.
Article in Heart (British Cardiac Society), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association between frailty and ischemic heart disease: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Effect of Milk and Other Dairy Products on the Risk of Frailty, Sarcopenia, and Cognitive Performance Decline in the Elderly: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Frailty Syndromes in Persons With Cerebrovascular Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention.Age and ageing · 2018Pooled it
- Long-Term Aspirin Use and Self-Reported Walking Speed in Older Men: The Physicians' Health Study.The Journal of frailty & aging · 2022Trial
- Inflammatory markers and clinical factors as key independent risk factors for frailty: a retrospective study.BMC geriatrics · 2025Article
- Association of frailty with non-laboratory based cardiovascular disease risk score among older adults and elderly population: insights from longitudinal aging study in India (LASI-1st wave).BMC public health · 2025Article
- Cardiovascular disease risk factors and frailty syndrome in community-dwelling older adults: Results from the Amirkola Health and Aging Project Cohort Study.BMC geriatrics · 2024Article
- Association of Cardiovascular Fibrosis, Remodeling, and Dysfunction With Frailty, Prefrailty, and Functional Performance: The Multi-Ethnic Study of Atherosclerosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Understanding the Causes of Frailty Using a Life-Course Perspective: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Frailty after COVID-19: The wave after?Aging medicine (Milton (N.S.W)) · 2023Review
- Impact of frailty on disease-specific health status in cardiovascular disease.Heart (British Cardiac Society) · 2023Review
- [The concept and practical management of frailty in neurology].Revista de neurologia · 2023Review
- Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study.Environmental health perspectives · 2023Article
- Utility of SCORE2 risk algorithm for predicting life course accelerated frailty and physical function decline.Journal of cachexia, sarcopenia and muscle · 2023Article
- Analysis of the status of social frailty in Chinese older adults with cardiovascular and cerebrovascular diseases: a national cross-sectional study.Frontiers in public health · 2023Article
- Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Associations between kidney function and outcomes of comprehensive cardiac rehabilitation in patients with heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Observational
- Contribution of muscle satellite cells to sarcopenia.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesTo examine the capacity of existing cardiovascular disease (CVD) risk algorithms widely used in primary care, to predict frailty.
designProspective cohort study. Risk algorithms at baseline (1997-1999) were the Framingham CVD, coronary heart disease and stroke risk scores, and the Systematic Coronary Risk Evaluation.
settingCivil Service departments in London, UK.
participants3895 participants (73% men) aged 45-69 years and free of CVD at baseline.
main outcome measureStatus of frailty at the end of follow-up (2007-2009), based on the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength and weight loss.
resultsAt the end of the follow-up, 2.8% (n=108) of the sample was classified as frail. All four CVD risk scores were associated with future risk of developing frailty, with ORs per one SD increment in the score ranging from 1.35 (95% CI 1.21 to 1.51) for the Framingham stroke score to 1.42 (1.23 to 1.62) for the Framingham CVD score. These associations remained after excluding incident CVD cases. For comparison, the corresponding ORs for the risk scores and incident cardiovascular events varied between 1.36 (1.15 to 1.61) and 1.64 (1.50 to 1.80) depending on the risk algorithm.
conclusionsThe use of CVD risk scores in clinical practice may also have utility for frailty prediction.
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