ArticleJournal of healthcare engineering2013
Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo.
Article in Journal of healthcare engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Assessing Enhanced Acoustic Absorption From Sonosensitive Perfluorocarbon Emulsion With Magnetic Resonance-Guided High-Intensity Focused Ultrasound and a Percolated Tissue-Mimicking Flow Phantom.Ultrasound in medicine & biology · 2023Article
- Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets.Ultrasound in medicine & biology · 2022Article
- A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy.International journal of nanomedicine · 2021Article
- Perfluorocarbon Emulsion Contrast Agents: A Mini Review.Frontiers in chemistry · 2021Review
- Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.Ultrasound in medicine & biology · 2020Review
- Article
- Enhancement of HIFU thermal therapy in perfused tissue models using micron-sized FTAC-stabilized PFOB-core endovascular sonosensitizers.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Article
- Effects of droplet size and perfluorocarbon boiling point on the frequency dependence of acoustic vaporization threshold.The Journal of the Acoustical Society of America · 2019Article
- MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform.Medical physics · 2019Article
- Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics.BioMed research international · 2019Review
- Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment.Ultrasound in medicine & biology · 2019Article
- Perfluorocarbon nanodroplets can reoxygenate hypoxic tumorsNanotheranostics · 2019Article
- Simultaneous Passive Acoustic Mapping and Magnetic Resonance Thermometry for Monitoring of Cavitation-Enhanced Tumor Ablation in Rabbits Using Focused Ultrasound and Phase-Shift Nanoemulsions.Ultrasound in medicine & biology · 2018Article
- Acoustic vaporization threshold of lipid-coated perfluoropentane droplets.The Journal of the Acoustical Society of America · 2018Article
- Role of Surface Tension in Gas Nanobubble Stability Under Ultrasound.ACS applied materials & interfaces · 2018Article
- Combined passive acoustic mapping and magnetic resonance thermometry for monitoring phase-shift nanoemulsion enhanced focused ultrasound therapy.Physics in medicine and biology · 2017Article
- Novel method for the formation of monodisperse superheated perfluorocarbon nanodroplets as activatable ultrasound contrast agents.RSC advances · 2017Article
- Optimizing Acoustic Activation of Phase Change Contrast Agents With the Activation Pressure Matching Method: A Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Review
- Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing.Advanced healthcare materials · 2015Article
- Acoustic Cavitation-Mediated Delivery of Small Interfering Ribonucleic Acids with Phase-Shift Nano-Emulsions.Ultrasound in medicine & biology · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) is being explored as a non-invasive technology to treat solid tumors. However, the clinical use of HIFU for tumor ablation applications is currently limited by the long treatment times required. Phase-shift nanoemulsions (PSNE), consisting of liquid perfluorocarbon droplets that can be vaporized into microbubbles, are being developed to accelerate HIFU-mediated heating. The purpose of this study was to examine accumulation of PSNE in intramuscular rabbit tumors in vivo. MR images were acquired before and after intravenous injection of gadolinium-containing PSNE. MR signal enhancement was observed in rabbit tumors up to six hours after injection, indicating that PSNE accumulated in the tumors. In addition, PSNE vaporization was detected in the tumor with B-mode ultrasound imaging, and MR thermometry measurements indicated that PSNE accelerated the rate of HIFU-mediated heating. These results suggest that PSNE could dramatically improve the efficiency and clinical feasibility of MRgHIFU.
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