Evidence map›Paper›PMID 23502042›Full record

ArticleBone2013

Osteoporosis medication adherence: physician perceptions vs. patients' utilization.

Jeffrey R Curtis, Qian Cai, Sally W Wade, Bradley S Stolshek, John L Adams, Akhila Balasubramanian, Hema N Viswanathan, Joel D Kallich

Open access · greenAbstract read
In one paragraph

Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

  1. Evaluation of a Remote Therapeutic Monitoring Device and Integrated Care Platform in Outpatient Parenteral Antimicrobial Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Trial
  2. Improving adherence to and persistence with oral therapy of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Long-Term Use of Oral Bisphosphonates and Fracture Risk in Men with Traumatic Spinal Cord Injury.Journal of physical medicine and rehabilitation (Wilmington, Del.) · 2020
    Article
  8. Observational
  9. Observational
  10. Article
  11. Observational
  12. Osteoporosis: a discussion on the past 5 years.Current reviews in musculoskeletal medicine · 2017
    Review
  13. Geographic variation in secondary fracture prevention after a hip fracture during 1999-2013: a UK study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  14. Article
  15. Long-term persistence with anti-osteoporosis drugs after fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  16. Validation of the Osteoporosis-Specific Morisky Medication Adherence Scale in long-term users of bisphosphonates.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014
    Article
  17. PINP as a biological response marker during teriparatide treatment for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jeffrey R CurtisUniversity of Alabama at Birmingham, FOT 805D, 510 20th Street South, Birmingham, AL 35294, USA. jcurtis@uab.edu
Qian Cai
Sally W Wade
Bradley S Stolshek
John L Adams
Akhila Balasubramanian
Hema N Viswanathan
Joel D Kallich
Amgen (United States) · USRAND Corporation · USUniversity of Alabama at Birmingham · USWilmington University · US

Funding

Longitudinal Comparative Effectiveness & Safety of Biologics in AutoimmunityR01HS018517 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURTIS, JEFFREY R. · 2009 to 2013
$2.2M
Ethnic Differences in the Risk of Fracture and Vascular DiseaseK23AR053351 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURTIS, JEFFREY R. · 2007 to 2011
$755k
AHRQ HHS R01 HS018517AHRQ HHS R01HS018517NIAMS NIH HHS AR053351NIAMS NIH HHS K23 AR053351
6 · The paper itself

Abstract

Few data are available on physician perceptions of osteoporosis medication adherence. This study compared physician-estimated medication adherence with adherence calculated from their patients' pharmacy claims. Women aged ≥45 years, with an osteoporosis-related pharmacy claim between January 1, 2005 and August 31, 2008, and continuous coverage for ≥12 months before and after first (index) claim, were identified from a commercial health plan population. Prescribing physicians treating ≥5 of these patients were invited to complete a survey on their perception of medication adherence and factors affecting adherence in their patients. Pharmacy claims-based medication possession ratio (MPR) was calculated for the 12-month post-index period for each patient. Physicians who overestimated the percentage of adherent (MPR ≥0.8) patients by ≥10 points were considered "optimistic". Logistic regression assessed physician characteristics associated with optimistic perception of adherence. A total of 376 (17.2%) physicians responded to the survey; 62.0% were male, 58.2% were aged 45 to 60 years, 55.3% had ≥20 years of practice, and 35.4% practiced in an academic setting. Participating physicians prescribed osteoporosis medications for 2748 patients with claims data (mean [SD] age of 62.0 [10.6] years). On average, physicians estimated 67.2% of their patients to be adherent; however, only 40% of patients were actually adherent based on pharmacy data. Optimistic physicians (73.4%) estimated 71.9% of patients to be adherent while only 32.2% of their patients were adherent based on claims data. Physicians in academic settings were more likely to be optimistic than community-based physicians (odds ratio 1.69, 95% CI: 1.01, 2.85). Overestimation of medication adherence may impede physicians' ability to provide high quality care for their osteoporosis patients.

Indexed as

Drug MonitoringHealth Knowledge, Attitudes, PracticeAdultAgedDemographyFemaleFollow-Up StudiesHealth SurveysHumansLogistic ModelsMaleMiddle AgedOsteoporosisPharmaciesPhysiciansUnited States

Identifiers

PMID23502042
PMCPMC3777338
OpenAlexW2139011815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.