Evidence map›Paper›PMID 23501967›Full record

ArticlePsychological science2013

Common DNA markers can account for more than half of the genetic influence on cognitive abilities.

Robert Plomin, Claire M A Haworth, Emma L Meaburn, Thomas S Price, Wellcome Trust Case Control Consortium 2, Oliver S P Davis

Abstract readTwin Study
In one paragraph

Article in Psychological science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
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  17. Review
  18. The new genetics of intelligence.Nature reviews. Genetics · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert PlominMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK. robert.plomin@kcl.ac.uk
Claire M A Haworth
Emma L Meaburn
Thomas S Price
Wellcome Trust Case Control Consortium 2
Oliver S P Davis

Funding

Genetics, School environments and cognitive developmentR01HD044454 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2005 to 2014
$3.4M
GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIESR01HD046167 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETRILL, STEPHEN A · 2003 to 2005
$1.6M
European Research Council 295366Medical Research Council G0500079Medical Research Council G0500079(73692)Medical Research Council G0901245Medical Research Council G19/2Medical Research Council G19/2(78332)NICHD NIH HHS HD044454NICHD NIH HHS HD046167NICHD NIH HHS R01 HD044454NICHD NIH HHS R01 HD046167Wellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/ZWellcome Trust WT088984
6 · The paper itself

Abstract

For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal, and general) with GCTA estimates captured by 1.7 million DNA markers. We found that DNA markers tagged by the array accounted for .66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities.

Indexed as

ChildCognitionGenetic MarkersGenome-Wide Association StudyGenotypeHumansIntelligencePhenotypePolymorphism, Single NucleotideTwins, DizygoticTwins, MonozygoticGenetic Markers

Identifiers

PMID23501967
PMCPMC3652710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.