ArticleJournal of the American College of Cardiology2013
Magnitude and time course of changes induced by continuous-flow left ventricular assist device unloading in chronic heart failure: insights into cardiac recovery.
Article in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02547766 (Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Value of Natriuretic Peptides for All-Cause Mortality, Right Ventricular Failure, Major Adverse Events, and Myocardial Recovery in Advanced Heart Failure Patients Receiving a Left Ventricular Assist Device: A Systematic Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices.Circulation · 2014Trial
- Surgical Approaches to Left Ventricular Assist Device Deactivation: Lessons From Remission From Stage D Heart Failure.Annals of thoracic surgery short reports · 2026Article
- Initiation of Neurohormonal Blockade and Clinical Outcomes in HeartMate 3 LVAD Recipients During Index Implantation.Artificial organs · 2026Article
- Heart Replacement Therapy in Young Patients: A Comparative Analysis of HeartMate 3 LVAD and Heart Transplant Using MOMENTUM 3 and UNOS Registry.JACC. Heart failure · 2026Article
- International Utah Cardiac Recovery Symposium (U-CARS) 2025: Clinical Science Proceedings.Heart failure reviews · 2026Article
- Routine Echocardiographic Assessment in LVAD Patients-A Structured Approach to Acquisition and Interpretation.Journal of cardiovascular development and disease · 2026Review
- Association of Kidney Function With Myocardial Recovery and Adverse Events Following Left Ventricular Assist Device Circulatory Support.Journal of the American Heart Association · 2025Article
- From support to recovery: the evolving role of LVAD in reversing heart failure.Journal of cardiothoracic surgery · 2025Review
- Left Atrial Reverse Remodeling in Patients Supported With Durable Left Ventricular Assist Devices and Clinical Implications.Circulation. Heart failure · 2025Article
- A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.Circulation · 2025Article
- Deactivation of LVAD support for myocardial recovery-surgical perspectives.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Review
- Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support.Journal of the American Heart Association · 2024Article
- Cardiological Challenges Related to Long-Term Mechanical Circulatory Support for Advanced Heart Failure in Patients with Chronic Non-Ischemic Cardiomyopathy.Journal of clinical medicine · 2023Review
- LVAD therapy as a catalyst to heart failure remission and myocardial recovery.Clinical cardiology · 2023Review
- Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Article
- Baseline QRS duration associates with cardiac recovery in patients with continuous-flow left ventricular assist device implantation.American heart journal plus : cardiology research and practice · 2022Article
- Clinical myocardial recovery in advanced heart failure with long term left ventricular assist device support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Review
- Does cardiac recovery favorably impact adverse events and outcomes of LVAD patients?The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
objectivesThis study sought to prospectively investigate the longitudinal effects of continuous-flow left ventricular assist device (LVAD) unloading on myocardial structure and systolic and diastolic function.
backgroundThe magnitude, timeline, and sustainability of changes induced by continuous-flow LVAD on the structure and function of the failing human heart are unknown.
methodsEighty consecutive patients with clinical characteristics consistent with chronic heart failure requiring implantation of a continuous-flow LVAD were prospectively enrolled. Serial echocardiograms (at 1, 2, 3, 4, 6, 9, and 12 months) and right heart catheterizations were performed after LVAD implant. Cardiac recovery was assessed on the basis of improvement in systolic and diastolic function indices on echocardiography that were sustained during LVAD turn-down studies.
resultsAfter 6 months of LVAD unloading, 34% of patients had a relative LV ejection fraction increase above 50% and 19% of patients, both ischemic and nonischemic, achieved an LV ejection fraction ≥ 40%. LV systolic function improved as early as 30 days, the greatest degree of improvement was achieved by 6 months of mechanical unloading and persisted over the 1-year follow up. LV diastolic function parameters also improved as early as 30 days after LVAD unloading, and this improvement persisted over time. LV end-diastolic and end-systolic volumes decreased as early as 30 days after LVAD unloading (113 vs. 77 ml/m(2), p < 0.01, and 92 vs. 60 ml/m(2), p < 0.01, respectively). LV mass decreased as early as 30 days after LVAD unloading (114 vs. 95 g/m(2), p < 0.05) and continued to do so over the 1-year follow-up but did not reach values below the normal reference range, suggesting no atrophic remodeling after prolonged LVAD unloading.
conclusionsContinuous-flow LVAD unloading induced in a subset of patients, both ischemic and nonischemic, early improvement in myocardial structure and systolic and diastolic function that was largely completed within 6 months, with no evidence of subsequent regression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.