ReviewEuropean journal of pharmacology2013
The application of conditioning paradigms in the measurement of pain.
Review in European journal of pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The prophylactic effect of photobiomodulation therapy on pain perception due to infiltration injection: a randomized clinical trial.Clinical oral investigations · 2024Trial
- Assessing cognitive biases induced by acute formalin or hotplate treatment: an animal study using affective bias test.Frontiers in behavioral neuroscience · 2024Article
- Role of the Anterior Cingulate Cortex in Translational Pain Research.Neuroscience bulletin · 2021Review
- Bridging the Translational Divide in Pain Research: Biological, Psychological and Social Considerations.Frontiers in pharmacology · 2021Review
- Assessing the affective component of pain, and the efficacy of pain control, using conditioned place aversion in calves.Biology letters · 2019Article
- Punishment and reinforcement by opioid receptor agonists in a choice procedure in rats.Behavioural pharmacology · 2019Article
- Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.Pharmacological reviews · 2019Review
- Calf aversion to hot-iron disbudding.Scientific reports · 2019Article
- An inexpensive modified weight-bearing device assembled in-house for high throughput unbiased behavioral pain assessment in mice.HardwareX · 2018Article
- Approach-aversion in calves following injections.Scientific reports · 2018Article
- Effect of nicotine and alpha-7 nicotinic modulators on visceral pain-induced conditioned place aversion in mice.European journal of pain (London, England) · 2018Article
- Does monetary reward operantly enhance pain sensitivity over time? An experiment in healthy individuals.Journal of pain research · 2018Article
- Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury.Frontiers in molecular neuroscience · 2017Article
- Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model.Arthritis research & therapy · 2016Article
- Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice.Neuropharmacology · 2016Article
- Automated assessment of pain in rats using a voluntarily accessed static weight-bearing test.Physiology & behavior · 2015Article
- Pain and depression comorbidity: a preclinical perspective.Behavioural brain research · 2015Review
- Antihyperalgesic effects of imidazoline I(2) receptor ligands in rat models of inflammatory and neuropathic pain.British journal of pharmacology · 2014Article
- Molecular, cellular and behavioral changes associated with pathological pain signaling occur after dental pulp injury.Molecular painArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Pain is a private experience that involves both sensory and emotional components. Animal studies of pain can only be inferred by their responses, and therefore the measurement of reflexive responses dominates the pain literature for nearly a century. It has been argued that although reflexive responses are important to unveil the sensory nature of pain in organisms, pain affect is equally important but largely ignored in pain studies primarily due to the lack of validated animal models. One strategy to begin to understand pain affect is to use conditioning principles to indirectly reveal the affective condition of pain. This review critically analyzed several procedures that are thought to measure affective learning of pain. The procedures regarding the current knowledge, the applications, and their advantages and disadvantages in pain research are discussed. It is proposed that these procedures should be combined with traditional reflex-based pain measurements in future studies of pain, which could greatly benefit both the understanding of neural underpinnings of pain and preclinical assessment of novel analgesics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.