Alpha-synuclein and protein degradation pathways in Parkinson's disease: a pathological feed-back loop.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed.

1. Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes.Cell death & disease · 2014
   Trial
2. When Pathologies Collide: The Intersection of Tau and Alpha-Synuclein in Neurodegenerative Diseases.Molecular neurobiology · 2026
   Review
3. Knockout of Rab27b exacerbates neuropathology in alpha-synuclein mouse models.Acta neuropathologica communications · 2026
   Article
4. Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system.Frontiers in cell and developmental biology · 2026
   Review
5. Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
   Article
6. Incretin Mimetics Restore the ER-Mitochondrial Axis and Switch Cell Fate Towards Survival in LUHMES Dopaminergic-Like Neurons: Implications for Novel Therapeutic Strategies in Parkinson's Disease.Journal of Parkinson's disease · 2023
   Article
7. Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology.NPJ Parkinson's disease · 2022
   Article
8. Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity.Neural regeneration research · 2022
   Review
9. Autophagy in α-Synucleinopathies-An Overstrained System.Cells · 2021
   Review
10. Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
11. Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.Biomolecules · 2020
    Review
12. When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease.Frontiers in cell and developmental biology · 2020
    Review
13. Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease: Lights and Shadows.Cells · 2019
    Review
14. Microglia as modulators of exosomal alpha-synuclein transmission.Cell death & disease · 2019
    Article
15. Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.BMC neuroscience · 2018
    Article
16. Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.Progress in neurobiology · 2017
    Review
17. The Proteasome Inhibition Model of Parkinson's Disease.Journal of Parkinson's disease · 2017
    Review
18. Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.Neurotoxicity research · 2016
    Review
19. Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update.Neurotoxicity research · 2015
    Article
20. ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.Molecular therapy : the journal of the American Society of Gene Therapy · 2014
    Article

Corrections and comments

• Comment on
  Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?2012

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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