ReviewProgress in neurobiology2013
Pain and analgesia: the value of salience circuits.
Review in Progress in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 210 citations in OpenAlex.
- A true response of the brain network during electroacupuncture stimulation at scalp acupoints: An fMRI with simultaneous EAS study.Brain and behavior · 2023Trial
- The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination.Scientific reports · 2021Trial
- Pain in Parkinson's disease: bridging pathophysiology, clinical features, and personalized management.The journal of headache and pain · 2026Review
- Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human.bioRxiv : the preprint server for biology · 2026Article
- Self-Efficacy as a Central Mediator of Pain, Function, and Depression: Insights of a Cross-Sectional Analysis of Depersonalized Data from the German Pain e-Registry.Journal of clinical medicine · 2026Article
- Rethinking coping in chronic pain: a systematic review and dynamic interaction model of coping.Pain reports · 2026Review
- Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Autonomic-salience stability as a candidate Gate for awake low-dose ketamine: a systems neuroscience framework with a clinical anchor.Frontiers in systems neuroscience · 2026Article
- Prediction error coding as the computational basis for nocifensive and nocifensive-like behaviors.Frontiers in neuroscience · 2026Article
- Extracranial Hemodynamic Responses to a Noxious Cold Pressor Task Differ Between Persistent Post-Traumatic Headache and Healthy Controls.Journal of personalized medicine · 2025Article
- Psilocybin as a psychophysical adaptogen in chronic pain rehabilitation.The journal of pain · 2025Article
- Topological Reorganization and Resting-State Functional Connectivity in Functional Dyspepsia: Associations of Symptoms with Peripheral Cytokine Levels and Amygdala Nodal Centrality.Molecular neurobiology · 2025Article
- Pain integration of multimodal noxious stimulation based on the perceptual instruction.Proceedings. Biological sciences · 2025Article
- Altered cerebral blood flow and functional connectivity in sickle cell disease.Journal of sickle cell disease · 2025Article
- Mechanistic and Clinical Evaluation of Lever-Positioning Manipulation in Lumbar Disc Herniation: A Study Protocol for a Randomized Controlled Trial Using Rs-fMRI.Journal of pain research · 2025Article
- Impaired gastric and urinary but preserved cardiac interoception in women with endometriosis.PloS one · 2025Article
- Pathological features of post-stroke pain: a comprehensive analysis for subtypes.Brain communications · 2025Article
- The effect of expectancy on conditioned pain modulation: evidence from functional near-infrared spectroscopy.Frontiers in psychology · 2025Article
- Mindfulness, cognition, and long-term meditators: Toward a science of advanced meditation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Evaluating external and internal stimuli is critical to survival. Potentially tissue-damaging conditions generate sensory experiences that the organism must respond to in an appropriate, adaptive manner (e.g., withdrawal from the noxious stimulus, if possible, or seeking relief from pain and discomfort). The importance we assign to a signal generated by a noxious state, its salience, reflects our belief as to how likely the underlying situation is to impact our chance of survival. Importantly, it has been hypothesized that aberrant functioning of the brain circuits which assign salience values to stimuli may contribute to chronic pain. We describe examples of this phenomenon, including 'feeling pain' in the absence of a painful stimulus, reporting minimal pain in the setting of major trauma, having an 'analgesic' response in the absence of an active treatment, or reporting no pain relief after administration of a potent analgesic medication, which may provide critical insights into the role that salience circuits play in contributing to numerous conditions characterized by persistent pain. Collectively, a refined understanding of abnormal activity or connectivity of elements within the salience network may allow us to more effectively target interventions to relevant components of this network in patients with chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.