ArticleOsteoarthritis and cartilage2013
Reproductive status and sex show strong effects on knee OA in a baboon model.
Article in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Sex Specific Determinants in Osteoarthritis: A Systematic Review of Preclinical Studies.International journal of molecular sciences · 2020Pooled it
- Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.Journal of menopausal medicine · 2026Review
- Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders.Neurobiology of aging · 2023Article
- Reasons for the Sex Bias in Osteoarthritis Research: A Review of Preclinical Studies.International journal of molecular sciences · 2023Review
- Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model.Arthritis research & therapy · 2022Article
- Evolutionary insights into primate skeletal gene regulation using a comparative cell culture model.PLoS genetics · 2022Article
- Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration.Biomaterials translational · 2022Review
- An evolutionary perspective of DNA methylation patterns in skeletal tissues using a baboon model of osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Amniotic Suspension Allograft Modulates Inflammation in a Rat Pain Model of Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Article
- Assessment of DNA Methylation Patterns in the Bone and Cartilage of a Nonhuman Primate Model of Osteoarthritis.Cartilage · 2019Article
- A Macaca Fascicularis Knee Osteoarthritis Model Developed by Modified Hulth Combined with Joint Scratches.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Animal models of osteoarthritis: classification, update, and measurement of outcomes.Journal of orthopaedic surgery and research · 2016Review
- Osteoarthritic changes in vervet monkey knees correlate with meniscus degradation and increased matrix metalloproteinase and cytokine secretion.Osteoarthritis and cartilage · 2015Article
- On the predictive utility of animal models of osteoarthritis.Arthritis research & therapy · 2015Review
- Mortality in captive baboons (Papio spp.): a-23-year study.Journal of medical primatology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveWe aimed to characterize severity and occurrence of knee osteoarthritis (OA), and effects of age, sex, body mass, and reproductive status on population-level normal variation in this condition in the baboon, a natural model of human knee OA.
methodsWe visually inspected articular cartilage of distal right femora of 464 baboons (309 females, 155 males) and assigned an OA severity score (comparable to a modified Outerbridge score) from 1 = unaffected to 4 = advanced OA (eburnation). Presence/absence of osteophytes was recorded. We tested for significant effects of age, sex, body mass, and, in females, reproductive status (pre-, peri-, or post-menopausal) on OA. When appropriate, analyses were repeated on an age-matched subset (153 of each sex).
resultsKnee OA was more frequent and severe in older animals (P < 0.0001), but significant age variation was apparent in each severity grade. Sex differences within the younger and older age groups suggest that males develop knee OA earlier, but females progress more quickly to advanced disease. There is a strong relationship between reproductive status and OA severity grade in females (P = 0.0005) with more severe OA in peri- and post-menopausal female baboons, as in humans.
conclusionsIdiopathic knee OA is common in adult baboons. Occurrence and severity are influenced strongly by reproductive status in females, and by sex with regard to patterns of disease progression - providing an animal model to investigate sex-specific variation in OA susceptibility in which the environmental heterogeneity inherent in human populations is vastly reduced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.