ArticleCell reports2013
Blocking apoptotic signaling rescues axon guidance in Netrin mutants.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A stable NTN1 fluorescent reporter chicken reveals cell specific molecular signatures during optic fissure closure.Scientific reports · 2025Article
- Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.Nature communications · 2020Article
- Drosophila Netrin-B controls mushroom body axon extension and regulates courtship-associated learning and memory of a Drosophila fragile X syndrome model.Molecular brain · 2019Article
- A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways.Neural plasticity · 2019Review
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- The Role of Apoptotic Signaling in Axon Guidance.Journal of developmental biology · 2018Review
- Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis.Development (Cambridge, England) · 2017Article
- Article
- The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled.eLife · 2016Article
- Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.PLoS biology · 2016Article
- A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons.The Journal of cell biology · 2016Article
- Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons.Development (Cambridge, England) · 2016Article
- Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells.Biology open · 2015Article
- Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS.Nature neuroscience · 2013Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
Netrins are guidance cues that form gradients to guide growing axons. We uncover a mechanism for axon guidance by demonstrating that axons can accurately navigate in the absence of a Netrin gradient if apoptotic signaling is blocked. Deletion of the two Drosophila NetA and NetB genes leads to guidance defects and increased apoptosis, and expression of either gene at the midline is sufficient to rescue the connectivity defects and cell death. Surprisingly, pan-neuronal expression of NetB rescues equally well, even though no Netrin gradient has been established. Furthermore, NetB expression blocks apoptosis, suggesting that NetB acts as a neurotrophic factor. In contrast, neuronal expression of NetA increases axon defects. Simply blocking apoptosis in NetAB mutants is sufficient to rescue connectivity, and inhibition of caspase activity in subsets of neurons rescues guidance independently of survival. In contrast to the traditional role of Netrin as simply a guidance cue, our results demonstrate that guidance and survival activities may be functionally related.
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