ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2013
New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: a clinical review.
Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Recent advances (2022-2024) in eye-tracking for Parkinson's disease: a promising tool for diagnosing and monitoring symptoms.Frontiers in aging neuroscience · 2025Pooled it
- Antisaccades in Parkinson's Disease: A Meta-Analysis.Neuropsychology review · 2021Pooled it
- Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson's disease.Scientific reports · 2021Trial
- Changes in Saccadic Hypometria over Time to Monitor Parkinson's Disease Progression.Pharmaceutical medicine · 2026Observational
- A Sensorimotor Framework for the Neurorehabilitation of Oculomotor Dysfunction in Parkinson's Disease.Journal of clinical medicine · 2026Review
- Factor Analysis of the Neurological Evaluation Scale (NES) and Corresponding Brain Function and Structures.International journal of methods in psychiatric research · 2026Article
- Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior.Cell reports · 2026Article
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- Eye movement parameters as biomarkers for diagnosis and levodopa responsiveness in patients with Parkinson's disease.Aging clinical and experimental research · 2025Article
- Correlation between non-motor symptoms and eye movements in Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.Research square · 2025Article
- Eye movement and pupillary response abnormalities measured using virtual reality as biomarkers in the diagnosis of early-stage Parkinson's disease.Frontiers in neurology · 2025Article
- Smooth pursuit and memory saccades are impaired in early-stage Parkinson's disease patients.Frontiers in neurology · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.bioRxiv : the preprint server for biology · 2024Article
- Different patterns of acute saccadic response to levodopa in de novo Parkinson's disease.Journal of neurology · 2024Article
- Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.Neuroscience and biobehavioral reviews · 2024Review
- Oculomotor Dysfunction in Idiopathic and LRRK2-Parkinson's Disease and At-Risk Individuals.Journal of Parkinson's disease · 2024Article
- Noradrenergic modulation of saccades in Parkinson's disease.Brain communications · 2024Article
- The Pathophysiology of Gilles de la Tourette Syndrome: Changes in Saccade Performance by Low-Dose L-Dopa and Dopamine Receptor Blockers.Brain sciences · 2023Article
- Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
We reviewed basal ganglia (BG) dysfunction in Parkinson's disease (PD) based on recent findings on saccade performance. Hypometria in all saccade paradigms and impaired initiation of internally triggered saccades such as memory guided saccades (MGS) are reported, whereas visually guided saccades (VGS) are relatively spared, although they are also mildly affected. The ability to inhibit unwanted saccades is also impaired. We propose that three major drives converges on SC to determine the saccade abnormalities. The impairment in VGS may be caused by the excessive inhibition of SC due to the increased BG output, whereas for MGS, decreased activity of the frontal cortex-BG circuit may also be involved. The impaired suppression of unwanted saccades may result from the "leaky" inhibition of SC. When PD patients inspect pictures, they end up exploring a smaller area of them with smaller saccades compared to normal subjects. Levodopa slightly prolongs VGS latency and shortens MGS latency, by altering the balance between the direct and indirect pathways of the BG circuit. In contrast, deep brain stimulation of the subthalamic nucleus improves saccade hypometria in both VGS and MGS, presumably by acting relatively directly on the SC-substantia nigra pars reticulata pathway to remove the excessive SC inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.