ReviewFertility and sterility2013
Biomarkers identified with time-lapse imaging: discovery, validation, and practical application.
Review in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07076719 (Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis
Who cites it
40 citing papers in PubMed, 121 citations in OpenAlex.
- Using the Eeva Test™ adjunctively to traditional day 3 morphology is informative for consistent embryo assessment within a panel of embryologists with diverse experience.Journal of assisted reproduction and genetics · 2015Trial
- First cleavage signatures define a temporal trade-off and predict embryo fitness.Scientific reports · 2026Article
- EVATOM: an optical, label-free, machine learning assisted embryo health assessment tool.Communications biology · 2024Article
- Retinoic Acid Action in Cumulus Cells: Implications for Oocyte Development and In Vitro Fertilization.International journal of molecular sciences · 2024Article
- Cleavage Patterns of 9600 Embryos: The Importance of Irregular Cleavage.Journal of clinical medicine · 2023Article
- Time-lapse monitoring technologies for the selection of bovine in vitro fertilized embryos with high implantation potential.The Journal of reproduction and development · 2023Review
- A proof of concept for a deep learning system that can aid embryologists in predicting blastocyst survival after thaw.Scientific reports · 2022Article
- Incidence, dynamics and recurrences of reverse cleavage in aneuploid, mosaic and euploid blastocysts, and its relationship with embryo quality.Journal of ovarian research · 2022Article
- When craft kicks back: Embryo culture as knowledge production in the context of the transnational fertility industry.Social studies of science · 2022Article
- Long-term Hyperandrogenemia and/or Western-style Diet in Rhesus Macaque Females Impairs Preimplantation Embryogenesis.Endocrinology · 2022Article
- The presence of cytoplasmic strings in human blastocysts is associated with the probability of clinical pregnancy with fetal heart.Journal of assisted reproduction and genetics · 2021Article
- Embryonic Development in Relation to Maternal Age and Conception Probability.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- MicroRNAs secreted by human embryos could be potential biomarkers for clinical outcomes of assisted reproductive technology.Journal of advanced research · 2021Article
- Short-term Western-style diet negatively impacts reproductive outcomes in primates.JCI insight · 2021Article
- Assisted oocyte activation effects on the morphokinetic pattern of derived embryos.Journal of assisted reproduction and genetics · 2021Article
- Mining of variables from embryo morphokinetics, blastocyst's morphology and patient parameters: an approach to predict the live birth in the assisted reproduction service.JBRA assisted reproduction · 2020Review
- Morphokinetic parameters as auxiliary criteria for selection of blastocysts cultivated in a time-lapse monitoring system.JBRA assisted reproduction · 2020Article
- Influence of Different Quality Sperm on Early Embryo Morphokinetic Parameters and Cleavage Patterns: A Retrospective Time-lapse Study.Current medical science · 2020Article
- The palette of techniques for cell cycle analysis.FEBS letters · 2020Review
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
"Time-lapse markers," which are defined by time-lapse imaging and correlated with clinical outcomes, may provide embryologists with new opportunities for improving embryo selection. This article provides an overview of noninvasive biomarkers defined by time-lapse imaging studies. In addition to comprehensively reviewing the discovery of each time-lapse marker, it focuses on the criteria necessary for their successful integration into clinical practice, including [1] statistical and biological significance, [2] validation through prospective clinical studies, and [3] development of reliable technology to measure and quantify the time-lapse marker. Because manual analysis of time-lapse images is labor intensive and limits the practical use of the image data in the clinic, automated image analysis software platforms may contribute substantially to improvements in embryo selection accuracy. Ultimately, time-lapse markers that are based on a foundation of basic research, validated through prospective clinical studies, and enabled by a reliable quantification technology may improve IVF success rates, encourage broader adoption of single-embryo transfer, and reduce the risks associated with multiple gestation pregnancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.