Evidence map›Paper›PMID 23498944›Full record

ReviewCell2013

Nuclear positioning.

Gregg G Gundersen, Howard J Worman

Abstract readReview
In one paragraph

Review in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 280 papers.

0numbers the graph read from it
0cells of the map it votes in
280citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

280 citing papers in PubMed.

  1. Aspects of plant intelligence (ii).Plant signaling & behavior · 2026
    Review
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Novel homozygousTherapeutic advances in neurological disorders · 2026
    Article
  8. Review
  9. Article
  10. Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

220 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gregg G GundersenDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. ggg1@columbia.edu
Howard J Worman

Funding

Pathogenesis of Emery-Dreifuss Muscular DystrophyR01AR048997 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WORMAN, HOWARD J · 2003 to 2024
$7.1M
Role of Nucleo-cytoskeleton Interactions in Cell MigrationR01GM099481 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUNDERSEN, GREGG G · 2011 to 2019
$2.9M
Nucleocytoplasmic Interactions and Dynamics in Emery-Dreifuss Muscular DystrophyR01NS059352 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WORMAN, HOWARD J · 2007 to 2011
$1.9M
The Nucleocytoskeleton in Progeria and AgingR01HD070713 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUNDERSEN, GREGG G, WORMAN, HOWARD J · 2011 to 2015
$1.7M
NIAMS NIH HHS R01 AR048997NIAMS NIH HHS R01AR048997NICHD NIH HHS R01 HD070713NICHD NIH HHS R01HD070713NIGMS NIH HHS R01 GM099481NIGMS NIH HHS R01GM099481NINDS NIH HHS R01 NS059352NINDS NIH HHS R01NS059352
6 · The paper itself

Abstract

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the cell and how forces generated by the cytoskeleton are coupled to the nucleus to move it. The significance of proper nuclear positioning is underscored by numerous diseases resulting from genetic alterations in the toolbox proteins. Finally, we discuss how nuclear position may influence cellular organization and signaling pathways.

Indexed as

AnimalsBiomechanical PhenomenaCell NucleusCellsCytoskeletonHumansMicrotubules

Identifiers

PMID23498944
PMCPMC3626264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.