ArticleBiomaterials2013
Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation.Scientific reports · 2023Article
- In vitro modelling of human proprioceptive sensory neurons in the neuromuscular system.Scientific reports · 2022Article
- Review
- In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like.Cells · 2020Article
- Chemotherapy-Induced Neuropathy and Drug Discovery Platform Using Human Sensory Neurons Converted Directly from Adult Peripheral Blood.Stem cells translational medicine · 2019Article
- Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.Advanced healthcare materials · 2018Review
- Fingolimod induces neuronal-specific gene expression with potential neuroprotective outcomes in maturing neuronal progenitor cells exposed to HIV.Journal of neurovirology · 2017Article
- Self-contained, low-cost Body-on-a-Chip systems for drug development.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Article
- Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.Biomaterials · 2017Article
- Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.American journal of stem cells · 2016Article
- Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- How multi-organ microdevices can help foster drug development.Advanced drug delivery reviews · 2014Review
- Microphysiological systems and low-cost microfluidic platform with analytics.Stem cell research & therapy · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although sensory neurons constitute a critical component for the proper function of the nervous system, the in vitro differentiation of functional sensory neurons from human stem cells has not yet been reported. This study presents the differentiation of sensory neurons (SNs) from a human neural progenitor cell line, hNP1, and their functional maturation in a defined, in vitro culture system without murine cell feeder layers. The SNs were characterized by immunocytochemistry and their functional maturation was evaluated by electrophysiology. Neural crest (NC) precursors, as one of the cellular derivatives in the differentiation culture, were isolated, propagated, and tested for their ability to generate sensory neurons. The hSC-derived SNs, as well as the NC precursors provide valuable tools for developing in vitro functional systems that model sensory neuron-related neural circuits and for designing therapeutic models for related diseases.
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Registered trials
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