ArticleAnnals of vascular surgery2013
Inflammatory "adiposopathy" in major amputation patients.
Article in Annals of vascular surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05457881 (Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease), which is not on this map. Cited by 12 papers.
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The trial behind it
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Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease
Who cites it
12 citing papers in PubMed.
- Perivascular adipose adiponectin correlates with symptom status of patients undergoing carotid endarterectomy.Stroke · 2015Trial
- The Predictive Role of Inflammatory Biomarkers and Their Correlation with the Biochemical Profile in Patients with Vasculopathy Undergoing Surgery.International journal of molecular sciences · 2024Article
- Adipose tissue: a neglected organ in the response to severe trauma?Cellular and molecular life sciences : CMLS · 2022Review
- Novel insights into the pathological mechanisms of metabolic related dyslipidemia.Molecular biology reports · 2021Review
- Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases.Molecular biology reports · 2020Review
- The Important Role of Leptin in Modulating the Risk of Dermatological Diseases.Frontiers in immunology · 2020Review
- Local Adipose-Associated Mediators and Adaptations Following Arteriovenous Fistula Creation.Kidney international reports · 2018Article
- Local perivascular adiponectin associates with lower extremity vascular operative wound complications.Surgery · 2016Article
- Diet-induced obesity drives negative mouse vein graft wall remodeling.Journal of vascular surgery · 2014Article
- Adiposopathy, "sick fat," Ockham's razor, and resolution of the obesity paradox.Current atherosclerosis reports · 2014Review
- Diversity of lipid mediators in human adipose tissue depots.American journal of physiology. Cell physiology · 2013Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundMuch has been made of obesity's health impact, largely founded on data regarding patient weight and circulating adipose-derived mediator levels. Paradoxically, a "healthy obese" state exists, but substantial knowledge gaps also exist regarding human adipose-phenotype determinants. Surgical major amputation (AMP) patients are the "sickest-of-the-sick." Conversely, elective knee replacement (TKR) is reserved for patients who expect continued health and longevity. To delineate human adipose biology variability and clinical determinants, we studied fresh subcutaneous adipose from AMP patients, using TKR patients as controls. We hypothesized that AMP patients would display a pro-inflammatory adipokine signature, and that certain clinical conditions (diabetes, hypertension, hyperlipidemia, high BMI, uremia) would independently drive elevated adipose inflammation.
methodsAMP (n = 29) and TKR (n = 20) adipose tissue samples and clinical data were collected prospectively, and protein was isolated and analyzed for 8 adipose-related mediators. Statistical analyses included Wilcoxon's rank sum test, Fisher's exact test, and multiple linear regression modeling of clinical parameter predictors of mediator expression.
resultsInterleukin-(IL)-6, IL-8, leptin, resistin, and PAI-1 were differentially expressed (up to 200-fold) between AMP/TKR cohorts. Key clinical parameters that associated with protein levels of adipose phenotype included age, gender, hypertension, hyperlipidemia, congestive heart failure, cerebrovascular disease, renal disease, and warfarin, statin, and insulin use. BMI failed to be predictive.
conclusionsAMP patients display adiposopathy with a pro-inflammatory adipose phenotypic signature compared with TKR controls. BMI fails to predict phenotype, yet other clinical conditions, such as age, hyperlipidemia, and renal insufficiency, do drive adipokine expression. Understanding human adipose phenotypic determinants stands as a fundamental priority when future studies dissect the interplay between adipose biology and surgical diseases/outcomes.
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