ArticleSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde2012
Antiretroviral treatment uptake in patients with HIV-associated TB attending co-located TB and ART services.
Article in South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol.Implementation science : IS · 2017Trial
- A Retrospective Analysis Examining the Impact of Educational Attainment and Social Determinants of Health on Rifampicin-Resistant Tuberculosis Treatment Outcomes.Open forum infectious diseases · 2026Article
- Gender difference in mortality among pulmonary tuberculosis HIV co-infected adults aged 15-49 years in Kenya.PloS one · 2020Article
- High uptake of antiretroviral therapy among HIV-positive TB patients receiving co-located services in Swaziland.PloS one · 2018Article
- Delay in the Provision of Antiretroviral Therapy to HIV-infected TB Patients in Nigeria.Universal journal of public health · 2017Article
- Article
- Timing of antiretroviral therapy and regimen for HIV-infected patients with tuberculosis: the effect of revised HIV guidelines in Malawi.BMC public health · 2014Observational
- Biomedical research, a tool to address the health issues that affect African populations.Globalization and health · 2013Article
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7 authors.
Funding
Abstract
backgroundDelivery of integrated care for patients with HIV-associated TB is challenging. We assessed the uptake and timing of antiretroviral treatment (ART) among eligible patients attending a primary care service with co-located ART and TB clinics.
methodsIn a retrospective cohort study, all HIV-associated TB patients (≥18 years old) who commenced TB treatment in 2010 were included. Data were analysed using basic descriptive statistics and log-binomial regression analysis.
resultsOf a total of 497 patients diagnosed with HIV-associated TB, 274 were eligible to start ART for the first time (median CD4 count, 159 cells/µl). ART was started during TB treatment by 220 (80.3%) patients. Among the 54 (19.7%) who did not start ART, 23 (42.6%) were either lost to follow-up (LTFU) or died before enrolling for ART; 12 (22.2%) were either LTFU or died after enrolling but before starting ART; 5 (9.3%) were transferred out; and 14 (25.9%) only started ART after completion of TB treatment. The median delay between starting TB treatment and starting ART was 51 days (IQR 29 - 77). Overall, only 58.6% of patients started ART within 8 weeks of TB treatment, and 12.7% of those with CD4 counts <50 cells/µl started ART within 2 weeks.
conclusionsIn a setting with co-located TB and ART clinics, delays to starting ART were substantial, and one-fifth of eligible patients did not start ART during TB treatment. Co-location of services alone is insufficient to permit timely initiation of ART; further measures need to be implemented to facilitate integrated treatment.
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