ArticleCough (London, England)2013
Sensorimotor circuitry involved in the higher brain control of coughing.
Article in Cough (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Efficacy of behavioral cough suppression therapy for refractory chronic cough or unexplained chronic cough: a meta-analysis of randomized controlled trials.Therapeutic advances in respiratory diseasePooled it
- Internet-Based Behavioral Cough Suppression Therapy for Refractory Chronic Cough: A Randomized Controlled Trial.American journal of speech-language pathology · 2025Trial
- Trial
- Physiological mechanisms and therapeutic targets in chronic cough.Physiological reports · 2026Review
- Personalized non-invasive neuromodulation for sensory-based urge suppression in individuals with OCD: a proof-of-concept investigation.Frontiers in human neuroscience · 2025Article
- Distinct sensorimotor cough features in a cohort of Progressive Supranuclear Palsy.Clinical parkinsonism & related disorders · 2025Article
- Identifying subgroups of urge suppression in Obsessive-Compulsive Disorder using machine learning.Journal of psychiatric research · 2024Article
- Well-Established and Traditional Use of Vegetal Extracts as an Approach to the "Deep Roots" of Cough.Children (Basel, Switzerland) · 2024Review
- Anodal transcranial direct current stimulation over the right primary somatosensory cortex increases cough reflex sensitivity: a pilot randomised controlled crossover trial.ERJ open research · 2023Article
- Prostaglandin ERespiratory research · 2021Article
- Assessment of cough in head and neck cancer patients at risk for dysphagia-An overview.Cancer reports (Hoboken, N.J.) · 2021Review
- Natural History, Phenotypic Spectrum, and Discriminative Features of Multisystemic RFC1 Disease.Neurology · 2021Article
- Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough.Clinical pharmacology and therapeutics · 2021Review
- Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.PloS one · 2021Article
- Gender Difference in Chronic Cough: Are Women More Likely to Cough?Frontiers in physiology · 2021Review
- Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat.Frontiers in physiology · 2021Article
- Coughs and Sneezes: Their Role in Transmission of Respiratory Viral Infections, Including SARS-CoV-2.American journal of respiratory and critical care medicine · 2020Review
- Female Guinea Pig Model for Cough Studies and Its Response to Most Common Tussive Substances.Physiological research · 2020Article
- Increased Gray Matter Density and Functional Connectivity of the Pons in Restless Legs Syndrome.Nature and science of sleep · 2020Article
- Voluntary upregulation of reflex cough is possible in healthy older adults and Parkinson's disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough is purely a reflex response to airways irritation is now superseded by the recognition that perception of an urge-to-cough and altered behavioral modification of coughing are key elements of cough disorders associated with airways disease. Understanding the pathways by which airway sensory nerves ascend into the brain and the patterns of neural activation associated with airways irritation will undoubtedly provide new insights into disordered coughing. This brief review aims to explore our current understanding of higher order cough networks by summarizing data from recent neuroanatomical and functional studies in animals and humans. We provide evidence for the existence of distinct higher order network components involved in the discrimination of signals arising from the airways and the motor control of coughing. The identification of these network components provides a blueprint for future research and the development of targeted managements for cough and the urge-to-cough.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.