ArticleGut pathogens2013
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III - convergence toward clinical trials.
Article in Gut pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression.The Australian and New Zealand journal of psychiatry · 2017Trial
- A case-series of oral acetate supplementation for gut microbiota alteration and metabolic improvement in patients with affective disorders on psychotropics.Translational psychiatry · 2026Article
- Navigating mental health in space: gut-brain axis and microbiome dynamics.Experimental & molecular medicine · 2025Review
- Latroeggtoxin-VI improves depression by regulating the composition and function of gut microbiota in a mouse model of depression.Journal of medical microbiology · 2025Article
- Review
- Estradiol metabolism by gut microbiota in women's depression pathogenesis: inspiration from nature.Frontiers in psychiatry · 2025Review
- The Influence of Intestinal Microbiota on BDNF Levels.Nutrients · 2024Review
- Research trends of next generation probiotics.Food science and biotechnology · 2024Review
- The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties.Microorganisms · 2024Review
- Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach-A Comprehensive Narrative Review.International journal of molecular sciences · 2023Review
- The promotion mechanism of prebiotics for probiotics: A review.Frontiers in nutrition · 2022Review
- A review on gut microbiota: a central factor in the pathophysiology of obesity.Lipids in health and disease · 2021Review
- Comparative Lipidomic Analysis of Extracellular Vesicles Derived fromInternational journal of molecular sciences · 2020Article
- Gut microbial clues to bipolar disorder: State-of-the-art review of current findings and future directions.Clinical and translational medicine · 2020Article
- Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience.Neurobiology of disease · 2020Review
- Traditional Chinese Medicine FormulaFrontiers in pharmacology · 2020Article
- Current Understanding of Gut Microbiota in Mood Disorders: An Update of Human Studies.Frontiers in genetics · 2019Review
- Article
- Impacts of Indoxyl Sulfate and p-Cresol Sulfate on Chronic Kidney Disease and Mitigating Effects of AST-120.Toxins · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid scientific and technological advances have allowed for a more detailed understanding of the relevance of intestinal microbiota, and the entire body-wide microbiome, to human health and well-being. Rodent studies have provided suggestive evidence that probiotics (e.g. lactobacillus and bifidobacteria) can influence behavior. More importantly, emerging clinical studies indicate that the administration of beneficial microbes, via supplementation and/or fecal microbial transplant (FMT), can influence end-points related to mood state (glycemic control, oxidative status, uremic toxins), brain function (functional magnetic resonance imaging fMRI), and mental outlook (depression, anxiety). However, despite the advances in the area of gastro-biological psychiatry, it becomes clear that there remains an urgent need to explore the value of beneficial microbes in controlled clinical investigations. With the history explored in this series, it is fair to ask if we are now on the cusp of major clinical breakthroughs, or are we merely in the quicksand of Autointoxication II?
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.