ArticleBMC medicine2013
Causes of death after fluid bolus resuscitation: new insights from FEAST.
Article in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial.Archives of disease in childhood · 2019Trial
- Article
- Fluid bolus therapy in pediatric sepsis: a narrative review.European journal of medical research · 2022Review
- Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial.The Lancet. Respiratory medicine · 2019Article
- Adjunctive therapy for severe malaria: a review and critical appraisal.Malaria journal · 2018Review
- Fluid Bolus Therapy in Pediatric Sepsis: Current Knowledge and Future Direction.Frontiers in pediatrics · 2018Review
- Personalised fluid resuscitation in the ICU: still a fluid concept?Critical care (London, England) · 2017Review
- Fluid resuscitation in human sepsis: Time to rewrite history?Annals of intensive care · 2017Review
- Fluid resuscitation-associated increased mortality and inflammatory cytokine expression in murine polymicrobial sepsis.Journal of clinical and translational science · 2017Article
- Update on pediatric sepsis: a review.Journal of intensive care · 2017Review
- Experts' recommendations for the management of cardiogenic shock in children.Annals of intensive care · 2016Article
- Predictors of Acute Hemodynamic Decompensation in Early Sepsis: An Observational Study.Journal of clinical medicine research · 2016Article
- Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care.Critical care (London, England) · 2015Article
- Early fluid accumulation in children with shock and ICU mortality: a matched case-control study.Intensive care medicine · 2015Article
- Addressing the Global Burden of Trauma in Major Surgery.Frontiers in surgery · 2015Review
- Pediatric sepsis: important considerations for diagnosing and managing severe infections in infants, children, and adolescents.Virulence · 2014Review
- Medicine for global health: can "simple interventions" improve the worldwide burden of disease?BMC medicine · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The Fluid Expansion as Supportive Therapy (FEAST study) was an extremely well conducted study that gave unexpected results. The investigators had reported that febrile children with impaired perfusion treated in low-income countries without access to intensive care are more likely to die if they receive bolus resuscitation with albumin or saline compared with no bolus resuscitation at all. In a secondary analysis of the trial, published in BMC Medicine, the authors found that increased mortality was evident in patients who presented with clinical features of severe shock in isolation or in conjunction with features of respiratory or neurological failure. The cause of excess deaths was primarily refractory shock and not fluid overload. These features are consistent with a potential cardiotoxic or ischemia-reperfusion injury following resuscitation with boluses of intravenous fluid. Although these effects may have been amplified by the absence of invasive monitoring, mechanical ventilation or vasopressors, the results provide compelling insights into the effects of intravenous fluid resuscitation and potential adverse effects that extend beyond the initial resuscitation period. These data add to the increasing body of literature about the safety and efficacy of intravenous resuscitation fluids, which may be applicable to management of other populations of critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.