Evidence map›Paper›PMID 23497404›Full record

Trial reportBMC medicine2013

A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial.

Ian D Cameron, Nicola Fairhall, Colleen Langron, Keri Lockwood, Noeline Monaghan, Christina Aggar, Catherine Sherrington, Stephen R Lord, Susan E Kurrle

6 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 203 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 15 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03457545 nacompletednot on this mapstarted 2015, after this paper: background citation

Pilot Study of a Home-based Exercise Intervention to Treat Frailty in Lung Transplant Candidates

TypeinterventionalSponsorUniversity of California, San FranciscoRan2015 to 2017Enrolled26ConditionsAdvanced Lung DiseaseArmsHome-based pulmonary rehabilitation, Aidcube
NCT03636412 nacompletednot on this mapstarted 2018, after this paper: background citation

Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients

TypeinterventionalSponsorThe Cleveland ClinicRan2018 to 2024Enrolled200ConditionsTransplant-Related Disorder, Frail Elderly Syndrome, Sarcopenia, Lung Graft DysfunctionArmsAmbulation
NCT03824106 narecruitingnot on this mapstarted 2022, after this paper: background citation

Frailty Rehabilitation: A Community-based Intervention to Promote Healthy Aging

TypeinterventionalSponsorMcMaster UniversityRan2022 to 2025Enrolled324ConditionsFrailtyArmsControl, Group Exercise, Nutrition and Medication review, Protein Supplement, Vitamin D
NCT03895931 completednot on this mapstarted 2019, after this paper: background citation

Effects of Pulmonary Rehabilitation on Frailty in Candidates for Lung Transplantation - a Prospective Observational Study

TypeobservationalSponsorSchön Klinik Berchtesgadener LandRan2019 to 2020Enrolled30ConditionsAdvanced Lung Disease, COPD, ILD
NCT04184180 completednot on this mapstarted 2019, after this paper: background citation

Effects of an Inpatient Pulmonary Rehabilitation Programme on Frailty in Patients After Lung-Transplantation

TypeobservationalSponsorKlaus KennRan2019 to 2020Enrolled33ConditionsAdvanced Lung Disease, COPD, Interstitial Lung Disease
NCT06753643 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Implementing the National Frailty Policy in Singapore's Primary Care: A Pilot Feasibility Study of The Intrinsic Capacity ProMotion in PrimAry Care for The Frail Program (IMPACTFrail)

TypeobservationalSponsorGeriatric Education and Research InstituteRan2025 to 2026Enrolled180ConditionsHealthy Ageing, FrailtyArmsThe IMPACTFrail programme
3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 15 syntheses or guidelines pooled it, 428 citations in OpenAlex.

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  14. Predicting risk and outcomes for frail older adults: an umbrella review of frailty screening tools.JBI database of systematic reviews and implementation reports · 2017
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143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ian D CameronRehabilitation Studies Unit, University of Sydney, PO Box 6, Ryde NSW 1680, Australia. ian.cameron@sydney.edu.au
Nicola Fairhall
Colleen Langron
Keri Lockwood
Noeline Monaghan
Christina Aggar
Catherine Sherrington
Stephen R Lord
Susan E Kurrle
University of Sydney · AUHornsby Ku-ring-gai Hospital · AUNeuroscience Research Australia · AUThe George Institute for Global Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrailty is a well known and accepted term to clinicians working with older people. The study aim was to determine whether an intervention could reduce frailty and improve mobility.

methodsWe conducted a single center, randomized, controlled trial among older people who were frail in Sydney, Australia. One group received an intervention targeting the identified characteristics of frailty, whereas the comparison group received the usual health care and support services. Outcomes were assessed by raters masked to treatment allocation at 3 and 12 months after study entry. The primary outcomes were frailty as assessed by the Cardiovascular Health Study criteria, and mobility as assessed by the Short Physical Performance Battery. Secondary outcome measures included disability, depressive symptoms and health-related quality of life.

resultsA total of 216 participants (90%) completed the study. Overall, 68% of participants were women and the mean age was 83.3 years (standard deviation, 5.9). In the intention-to-treat analysis, the between-group difference in frailty was 14.7% at 12 months (95% confidence interval: 2.4%, 27.0%; P = 0.02). The score on the Short Physical Performance Battery, in which higher scores indicate better physical status, was stable in the intervention group and had declined in the control group; with the mean difference between groups being 1.44 (95% confidence interval, 0.80, 2.07; P <0.001) at 12 months. There were no major differences between the groups with respect to secondary outcomes. The few adverse events that occurred were exercise-associated musculoskeletal symptoms.

conclusionsFrailty and mobility disability can be successfully treated using an interdisciplinary multifaceted treatment program.

trial registrationAustralia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12608000250336.

Indexed as

Mobility LimitationPatient Care TeamActivities of Daily LivingAgedAged, 80 and overExercise TherapyFemaleFollow-Up StudiesFrail ElderlyHumansMaleQuality of Life

Identifiers

PMID23497404
PMCPMC3751685
OpenAlexW2014910485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.