ArticleParticle and fibre toxicology2013
Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats.
Article in Particle and fibre toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases.Pharmaceutics · 2025Review
- Exploring In Vivo Pulmonary and Splenic Toxicity Profiles of Silicon Quantum Dots in Mice.Materials (Basel, Switzerland) · 2024Article
- In vitro inflammation and toxicity assessment of pre- and post-incinerated organomodified nanoclays to macrophages using high-throughput screening approaches.Particle and fibre toxicology · 2024Article
- Review
- Glucose determination in human serum by applying inner filter effect quenching mechanism of upconversion nanoparticles.Frontiers in bioengineering and biotechnology · 2023Article
- Recent advances in nanoparticle applications in respiratory disorders: a review.Frontiers in pharmacology · 2023Review
- Effect of CaS Nanostructures in the Proliferation of Human Breast Cancer and Benign Cells In Vitro.Applied sciences (Basel, Switzerland) · 2022Article
- U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials.ALTEX · 2022Article
- Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2021Review
- Applications and Immunological Effects of Quantum Dots on Respiratory System.Frontiers in immunology · 2021Review
- In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quantum Dots with Different Surface Modifications.International journal of nanomedicine · 2020Article
- Toxicity Evaluation of Quantum Dots (ZnS and CdS) Singly and Combined in Zebrafish (International journal of environmental research and public health · 2019Article
- Visualizing the Fate of Intra-Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near-Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Quantum dots and mouse strain influence house dust mite-induced allergic airway disease.Toxicology and applied pharmacology · 2019Article
- Cardiotoxicity of Intravenously Administered CdSe/ZnS Quantum Dots in BALB/c Mice.Frontiers in pharmacology · 2019Article
- In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Short-Term Pulmonary Toxicity Assessment of Pre- and Post-incinerated Organomodified Nanoclay in Mice.ACS nano · 2018Article
- Autonomous Synthesis of Fluorescent Silica Biodots Using Engineered Fusion Proteins.ACS omega · 2018Article
- Cytotoxicity of InP/ZnS Quantum Dots With Different Surface Functional Groups Toward Two Lung-Derived Cell Lines.Frontiers in pharmacology · 2018Article
- Biological behaviors and chemical fates of AgToxicology research · 2017Article
Corrections and comments
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe potential use of quantum dots (QD) in biomedical applications, as well as in other systems that take advantage of their unique physiochemical properties, has led to concern regarding their toxicity, potential systemic distribution, and biopersistence. In addition, little is known about workplace exposure to QD in research, manufacturing, or medical settings. The goal of the present study was to assess pulmonary toxicity, clearance, and biodistribution of QD with different functional groups in rats after pulmonary exposure.
methodsQD were composed of a cadmium-selenide (CdSe) core (~5nm) with a zinc sulfide (ZnS) shell functionalized with carboxyl (QD-COOH) or amine (QD-NH2) terminal groups. Male Sprague-Dawley rats were intratracheally-instilled (IT) with saline, QD-COOH, or QD-NH2 (12.5, 5.0, or 1.25 μg/rat). On days 0, 1, 3, 5, 7, 14, and 28 post-IT, the left lung, lung-associated lymph nodes (LALN), heart, kidneys, spleen, liver, brain, and blood were collected for metal analysis of Cd content by neutron activation to evaluate clearance and biodistribution. One right lobe was ligated and fixed for microscopy and histopathological analysis. The remaining right lobes from rats in each group were subjected to bronchoalveolar lavage (BAL) to retrieve BAL fluid and cells for analysis of injury and inflammation.
resultsLung injury and inflammation was found to be dose-dependent and peaked at days 7 and 14 post-exposure for both forms of QD, with slight variations in degree of toxicity at early and later time points. Both QD appeared to lose their fluorescent properties and destabilize after 1 week in the lung. Cd persisted up to 28 days for both forms of QD; however, clearance rate was slightly greater for QD-COOH over time. No Cd was detected in the liver, spleen, heart, brain, or blood at any time point. Cd appeared in the LALN and kidneys beginning at 1-2 weeks post-exposure.
conclusionsQD-COOH and QD-NH2 differed in clearance rate and differed slightly in degree of toxicity at different time points; however, the overall pattern of toxicity and biodistribution was similar between the two particles. Toxicity may be dependent on the dissolution rate and bioavailability of free Cd.
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