ArticleBMC health services research2013
Comparison of prothrombin time (INR) results and main characteristics of patients on warfarin treatment in primary health care centers and anticoagulation clinics.
Article in BMC health services research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy.Blood advances · 2018Guideline
- Time in Therapeutic Range in Patients with Venous Thromboembolism on Vitamin K Antagonist in a Moroccan Thrombosis Unit : An Observational Study.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Low Quality of Warfarin Therapy is Associated With Female Gender but Not With Polypharmacy in Patients With Atrial Fibrillation.Frontiers in pharmacology · 2021Article
- Clinically relevant drug-drug interactions among elderly people with dementia.European journal of clinical pharmacology · 2018Article
- Characteristics of patients with thromboembolic disorders on warfarin therapy in resource limited settings.BMC health services research · 2018Article
- Analytical Management of Patients Undergoing Oral Anticoagulant Therapy Could Have a Strong Impact on Clinical Outcomes: A Follow-up Study.Cardiology and therapy · 2017Article
- Impact of age on long-term anticoagulation and how gender and monitoring setting affect it: implications for decision making and patient management.British journal of clinical pharmacology · 2016Article
- Profile and anticoagulation outcomes of patients on warfarin therapy in an urban hospital in Cape Town, South Africa.African journal of primary health care & family medicine · 2016Article
- A project to improve the management of patients on warfarin in a primary care setting through the introduction of a POC analysis.BMJ quality improvement reports · 2016Article
- Introduction of point of care analysis for prescribing warfarin at a Swedish primary care centre.BMJ quality improvement reports · 2015Article
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3 authors.
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Abstract
backgroundOral anticoagulant therapy is used to prevent thrombosis in patients with atrial fibrillation (AF), venous thrombosis and prosthetic heart valves. The introduction of new therapies emphasizes the need to discern the best practice for the patients remaining on warfarin treatment. This study compares patient characteristics and therapeutic control in two settings managing warfarin treatment: Swedish primary health care centers (PHCC) and specialized anticoagulation clinics (ACC).
methodsProthrombin time (PT) test results reported as International Normalized Ratio (INR) were collected for five consecutive days from patients on warfarin treatment; 564 PHCC and 927 ACC patients. Therapeutic control was calculated as PT test results in relation to intended therapeutic range (TR). Mann-Whitney Rank Sum Test and Chi2 test were used for statistical comparisons.
resultsThe PHCC patients were older than the ACC patients, 76 v. 70 years (p<0.01) with a predominance of men in both groups. The reasons for treating differed between the groups. Seventy-two percent of PHCC patients and 66% of ACC patients had a PT-INR within the intended TR (p<0.05). Men generally had better results than women (72% v. 63%, p<0.001) and particularly in the PHCC group v. the ACC group (78% v. 69%, p<0.01).PT-INR above intended TR was significantly more common in the ACC setting, (p<0.05), for women overall (p<0.01), for women in the PHCC setting, and for ACC men (p<0.05).
conclusionsIn this study both settings achieved good therapeutic control of warfarin treatment with a minor advantage for PHCC over ACC, and better results for men, especially in the PHCC setting. As patient characteristics differ between the PHCC and ACC, it is important to conduct further randomized studies to discern the best practice locally for warfarin management also after the introduction of new drugs.
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