ArticleBMC infectious diseases2013
Severe imported falciparum malaria among adults requiring intensive care: a retrospective study at the hospital for tropical diseases, London.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evidence of malarial chemoprophylaxis among travellers who died from malaria: a systematic review and meta-analysis.Malaria journal · 2023Pooled it
- Imported falciparum malaria among adults requiring intensive care: analysis of the literature.Malaria journal · 2014Pooled it
- Beyond the mouse: organoids, spheroids, and organs-on-chips as the (inevitable) future of malaria research?Malaria journal · 2026Review
- Assessment of Long-Term Sequelae After Severe Malaria: A Retrospective Study.Pathogens (Basel, Switzerland) · 2026Article
- Malaria: 11-Year Experience With Imported Cases at a German University Hospital and Epidemiological Trends Amid the COVID-19 Pandemic.Journal of parasitology research · 2026Article
- Management and monitoring strategies for severe cerebral malaria: a guide for the intensivist.Annals of intensive care · 2025Review
- Diagnosis and management of malaria in the intensive care unit.Journal of intensive medicine · 2024Review
- Emerging and Re-Emerging Parasitic Infections of the Central Nervous System (CNS) in Europe.Infectious disease reports · 2023Review
- Use of artesunate in the treatment of severe imported malaria in France: review of the effectiveness and real-life safety in two French university hospitals.BMC infectious diseases · 2023Observational
- Factors Associated with Severe Malaria among Patients under Reference to District Hospitals: A Cross-Sectional Study in Rusizi District, Rwanda.Rwanda journal of medicine and health sciences · 2023Article
- Imported diseases in travellers presenting to the emergency department after a stay in a malaria-endemic country: a retrospective observational study.Tropical diseases, travel medicine and vaccines · 2023Article
- Severe Malaria in an Adult Patient from Low-Endemic Area in Flores Island, East Nusa Tenggara.Case reports in medicine · 2023Article
- The Emergence of Travel-related Infections in Critical Care Units.Journal of translational internal medicine · 2022Article
- Clinical manifestations and outcomes of severe malaria in adult patients admitted to a tertiary hospital in the Gambia.Malaria journal · 2022Article
- Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study.Journal of clinical medicine · 2020Article
- Mortality from malaria in France, 2005 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017.Annals of intensive care · 2020Article
- Imported Malaria at a Referral Hospital in Tokyo from 2005 to 2016: Clinical Experience and Challenges in a Non-Endemic Setting.The American journal of tropical medicine and hygiene · 2019Article
- Brain magnetic resonance imaging in imported malaria.Malaria journal · 2019Article
- Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundMalaria is the commonest imported infection in the UK. Malaria requiring ICU admission has a reported mortality of up to 25%. The relationship between ethnicity, immunity, and risk of malaria is complex. The Malaria Score for Adults (MSA) and Coma Acidosis Malaria (CAM) score have recently been proposed to risk stratify patients with malaria.
methodsRetrospective study of patients with WHO severe falciparum malaria admitted to ICU at the Hospital for Tropical Diseases, London, UK. The relationship between clinical variables and risk of death or a prolonged ICU stay were examined with logistic regression. The predictive value of the MSA and CAM score were calculated.
results124 patients were included. Cerebral malaria and acute kidney injury occurred earlier (median day 1) than acute respiratory distress syndrome (median day 3). Six patients had community acquired bacterial co-infection. Eight patients were co-infected with HIV, five of whom were newly diagnosed. The positive predictive value of a CAM score ≥2 or an MSA ≥5 for death were 12% and 22% respectively. Five patients died. No variable was significantly associated with risk of death. There were no significant differences between individuals raised in endemic countries compared to non-endemic countries.
conclusionsMortality in patients managed in a specialist centre was low. Patients who died succumbed to complications associated with a prolonged stay on ICU rather than malaria per se. The clinical usefulness of the MSA and CAM score was limited. Co-infection with HIV was relatively common but compared to studies in children, bacteraemia was uncommon. The relationship between ethnicity and immunity to severe disease is complex.
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