ArticleBMC biotechnology2013
The use of DNA from archival dried blood spots with the Infinium HumanMethylation450 array.
Article in BMC biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Detection of AdenoviralInternational journal of molecular sciences · 2026Article
- Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients.International journal of cancer · 2026Article
- Social relationships and epigenetic markers of aging in middle-aged and older adults: cross-sectional and prospective analyses.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Psychological distress in older adults: associations with epigenetic markers of ageing, inflammation, and depression, and joint effects on mortality.Brain, behavior, & immunity - health · 2025Article
- Association of Epigenetic Markers of Aging With Prevalent and Incident Type 2 Diabetes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Self-rated health, epigenetic ageing, and long-term mortality in older Australians.GeroScience · 2024Article
- Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?Epigenetics · 2022Article
- Article
- Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort.Environmental research · 2021Article
- Little to Give, Much to Gain-What Can You Do With a Dried Blood Spot?Current environmental health reports · 2020Review
- Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards.Epigenetics · 2020Article
- Integrating DNA methylation measures to improve clinical risk assessment: are we there yet? The case of BRCA1 methylation marks to improve clinical risk assessment of breast cancer.British journal of cancer · 2020Review
- Impact ofFrontiers in genetics · 2020Article
- Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood.Nature communications · 2019Article
- Inference about causation between body mass index and DNA methylation in blood from a twin family study.International journal of obesity (2005) · 2019Article
- Assessment of dried blood spots for DNA methylation profiling.Wellcome open research · 2019Article
- Generation Scotland participant survey on data collection.Wellcome open research · 2019Article
- Genome-wide DNA methylation assessment of 'BRCA1-like' early-onset breast cancer: Data from the Australian Breast Cancer Family Registry.Experimental and molecular pathology · 2018Article
- Novel associations between blood DNA methylation and body mass index in middle-aged and older adults.International journal of obesity (2005) · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDried blood (Guthrie card) spots provide an efficient way to collect and store blood specimens. DNA from this source has been utilised for a number of molecular analyses including genome-wide association studies, but only few studies have tested the feasibility of using it for epigenetic applications, particularly at a genome-wide level.
resultsIn this study, we demonstrate the successful use of DNA isolated from archived dried blood spots for the Infinium HumanMethylation450 Beadchip, along with DNA from matched frozen buffy coats. We obtained high quality and reproducible genome-wide DNA methylation profiles using both sample types. We also report high correlations (r > 0.9907) between DNA obtained from matched dried blood spots and frozen buffy coats, sufficient to distinguish between unrelated individuals.
conclusionsWe, thus, demonstrate that DNA from archived dried blood spots is suitable for genome-wide DNA methylation profiling.
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