ArticleBMC infectious diseases2013
Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 3 of them syntheses that pooled it.
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Who cites it
91 citing papers in PubMed, 3 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Association of Short-Term Exposure to Meteorological Factors and Risk of Hand, Foot, and Mouth Disease: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Temporal relationships between climate variables and hand-foot-mouth disease: a multi-province study in the Mekong Delta Region, Vietnam.International journal of biometeorology · 2020Pooled it
- The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis.The Pediatric infectious disease journal · 2016Pooled it
- Bayesian spatiotemporal analysis for association of environmental factors with hand, foot, and mouth disease in Guangdong, China.Scientific reports · 2018Trial
- Trial
- Predictive Modeling of Enterovirus Hospital Burden Using Machine Learning and Age-Specific Surveillance Data: Operational Forecasting in Taiwan During the Postpandemic Era.JMIR formative research · 2026Article
- Clinical and epidemiological characteristics of hospitalized children with enterovirus infection: a retrospective study from 2016 to 2025 at Beijing children's hospital.BMC infectious diseases · 2026Article
- Ambient air pollution and meteorological factors associated with hand, foot, and mouth disease risk in Shenzhen, China: a time-series study.Frontiers in public health · 2026Article
- Predicting the incidence of common intestinal infectious diseases in Changzhou, China based on environmental factors and deep learning.BMC public health · 2025Article
- Epidemiology of childhood enterovirus infections in Hangzhou, China, 2019-2023.Virology journal · 2024Article
- Article
- Study on association factors of intestinal infectious diseases based-Bayesian spatio-temporal model.BMC infectious diseases · 2023Article
- Study of the influence of meteorological factors on HFMD and prediction based on the LSTM algorithm in Fuzhou, China.BMC infectious diseases · 2023Article
- Effects of different levels of non-pharmaceutical interventions on hand, foot and mouth disease in Guangzhou, China.BMC public health · 2022Article
- Assessing the impact of ambient temperature on the risk of hand, foot, and mouth disease in Guangdong, China: New insight from the disease severity and burden.PLoS neglected tropical diseases · 2022Article
- Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020.BMC public health · 2022Article
- Effects of temperature and PMEnvironmental science and pollution research international · 2022Article
- Association between Meteorological Parameters and Hand, Foot and Mouth Disease in Mainland China: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2021Review
- Spatial and Temporal Characteristics of Hand-Foot-and-Mouth Disease and Their Influencing Factors in Urumqi, China.International journal of environmental research and public health · 2021Article
- The Influence of Average Temperature and Relative Humidity on New Cases of COVID-19: Time-Series Analysis.JMIR public health and surveillance · 2021Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the last decade, major outbreaks of hand, foot, and mouth disease (HFMD) have been reported in Asian countries, resulting in thousands of deaths among children. However, less is known regarding the effect of meteorological variables on the incidence of HFMD in children. This study aims at quantifying the relationship between meteorological variables and the incidence of HFMD among children in Guangzhou, China.
methodsThe association between weekly HFMD cases in children aged <15 years and meteorological variables in Guangzhou from 2008 to 2011 were analyzed using the generalized additive model (GAM) and time-series method, after controlling for long-term trend and seasonality, holiday effects, influenza period and delayed effects.
resultsTemperature and relative humidity with one week lag were significantly associated with HFMD infection among children. We found that a 1°C increase in temperature led to an increase of 1.86% (95% CI: 0.92, 2.81%) in the weekly number of cases in the 0-14 years age group. A one percent increase in relative humidity may lead to an increase of 1.42% (95% CI: 0.97, 1.87%) in the weekly number of cases in the 0-14 years age group.
conclusionsThis study provides quantitative evidence that the incidence of HFMD in children was associated with high average temperature and high relative humidity. The one-week delay in the effects of temperature and relative humidity on HFMD is consistent with the enterovirus incubation period and the potential time lag between onset of children's sickness and parental awareness and response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.