SynthesisBMC musculoskeletal disorders2013
Physical activity during life course and bone mass: a systematic review of methods and findings from cohort studies with young adults.
Synthesis in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Impact of physical activity and exercise on bone health in patients with chronic kidney disease: a systematic review of observational and experimental studies.BMC nephrology · 2020Pooled it
- Pooled it
- Effects of Exercise on Bone Status in Female Subjects, from Young Girls to Postmenopausal Women: An Overview of Systematic Reviews and Meta-Analyses.Sports medicine (Auckland, N.Z.) · 2016Pooled it
- Exercise-based injury prevention in child and adolescent sport: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2014Pooled it
- Effects of a 3-month weight-bearing and resistance exercise training on circulating osteogenic cells and bone formation markers in postmenopausal women with low bone mass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Trial
- Physical Activity Across Adulthood and Bone Health in Later Life: The 1946 British Birth Cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Soft tissues, areal bone mineral density and hip geometry estimates in active young boys: the PRO-BONE study.European journal of applied physiology · 2017Trial
- A glimpse into the impact of physical activity on linear growth in children and adolescents through activity restrictions accompanying the COVID-19 outbreak.BioMedicine · 2026Article
- The Crucial Role of Exercise in Promoting Adolescent Bone Health.Advances in experimental medicine and biology · 2026Review
- Nonalcoholic fatty liver disease may increase the risk of osteoporosis in middle aged adults: a 12-year longitudinal analysis from the Korean Genome and Epidemiology Study (KoGES).Archives of osteoporosis · 2025Article
- Variations over time in proximal femoral strength in young adult men are not explained by areal bone mineral density alone.JBMR plus · 2025Article
- Associations Between Youth Sport Participation and Bone, Muscle, and Fat in Adulthood: Iowa Bone Development Study.International journal of environmental research and public health · 2025Article
- Physical activity level among male and female middle to high school students and impact of perceived school climate: a longitudinal analysis.Frontiers in public health · 2025Article
- High-Protein Diets during either Resistance or Concurrent Training Have No Detrimental Effect on Bone Parameters in Resistance-Trained Males.Nutrients · 2024Article
- Micromechanical Loading Studies in Ex Vivo Cultured Embryonic Rat Bones Enabled by a Newly Developed Portable Loading Device.Annals of biomedical engineering · 2023Article
- The Decline of Physical Activity with Age in School-Aged Children with Cerebral Palsy: A Single-Center Cross-Sectional Observational Study.Journal of clinical medicine · 2023Article
- Effects of aging and reproductive history on bone parameters of common marmoset (Callithrix jacchus) mandibles.Experimental animals · 2023Article
- Esports players, got muscle? Competitive video game players' physical activity, body fat, bone mineral content, and muscle mass in comparison to matched controls.Journal of sport and health science · 2022Article
- Dietary inflammatory index and bone mineral density in Mexican population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Physical activity estimated by osteogenic potential and energy expenditure has differing associations with bone mass in young adults: the raine study.Archives of osteoporosis · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this paper was to review the literature of the cohort studies which evaluated the association between physical activity during the life course and bone mineral content or density in young adults.
methodsProspective cohort studies with bone mineral density or content measured in the whole body, lumbar spine and femoral neck by dual energy x-ray absorptiometry as outcome and physical activity as exposure were searched. Two independent reviewers selected studies retrieved from electronic databases (Medline, Lilacs, Web of Science and Scielo) and reviewed references of all selected full text articles. Downs & Black criterion was used in the quality assessment of these studies.
resultsNineteen manuscripts met inclusion criteria. Lumbar spine was the skeletal site most studied (n = 15). Different questionnaires were used for physical activity evaluation. Peak strain score was also used to evaluate physical activity in 5 manuscripts. Lack of statistical power calculation was the main problem found in the quality assessment. Positive associations between physical activity and bone mass were found more in males than in females; in weight bearing anatomical sites (lumbar spine and femoral neck) than in total body and when physical activity measurements were done from adolescence to adulthood - than when evaluated in only one period. Physical activity during growth period was associated with greater bone mass in males. It was not possible to conduct pooled analyses due to the heterogeneity of the studies, considering mainly the different instruments used for physical activity measurements.
conclusionsPhysical activity seems to be important for bone mass in all periods of life, but especially the growth period should be taking into account due to its important direct effect on bone mass and its influence in physical activity practice in later life. Low participation in peak strain activities may also explain the lower number of associations found in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.