ArticleBMC microbiology2013
Molecular analysis of non-O1/non-O139 Vibrio cholerae isolated from hospitalised patients in China.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Antimicrobial resistance among clinicalPathogens and global health · 2023Pooled it
- Whole Genome Characterisation of Non-O1/Non-O139Microorganisms · 2026Article
- Integrated Phenotypic and Genomic Analysis of Antimicrobial Resistance, Virulence, and Phylogeny inMicroorganisms · 2026Article
- Non-O1/Non-O139Microorganisms · 2024Review
- Emergence and genomic insights of non-pandemic O1Microbiology spectrum · 2023Article
- Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China.Biomolecules & biomedicine · 2023Article
- Environmental Drivers of Vibrio cholerae Abundances in Mobile Bay, Alabama.Microbiology spectrum · 2023Article
- Resistance ofFrontiers in pharmacology · 2023Review
- Distribution and Molecular Characteristics ofMicroorganisms · 2022Article
- Non-serogroup O1/O139 agglutinable Vibrio cholerae: a phylogenetically and genealogically neglected yet emerging potential pathogen of clinical relevance.Archives of microbiology · 2022Review
- Article
- Multilevel Genome Typing Describes Short- and Long-Term Vibrio cholerae Molecular Epidemiology.mSystems · 2021Article
- Population Structure and Multidrug Resistance of Non-O1/Non-O139 Vibrio cholerae in Freshwater Rivers in Zhejiang, China.Microbial ecology · 2021Article
- Virulence of Cholera Toxin Gene-PositiveFrontiers in microbiology · 2021Article
- A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.Journal of bacteriology · 2020Article
- Non-O1/non-O139Epidemiology and infection · 2020Review
- Two cases of septic shock with different outcomes caused by non-O1/non-O139The Journal of international medical research · 2020Article
- A molecular and epidemiological study of Vibrio cholerae isolates from cholera outbreaks in southern Ghana.PloS one · 2020Article
- Virulence Pattern and Genomic Diversity of Vibrio cholerae O1 and O139 Strains Isolated From Clinical and Environmental Sources in India.Frontiers in microbiology · 2020Article
- Oral Infection Caused by Non-O1/Non-O139Infection and drug resistance · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholera is still a significant public health issue in developing countries. The aetiological agent is Vibrio cholerae and only two serogroups, O1 and O139, are known to cause pandemic or epidemic cholera. In contrast, non-O1/non-O139 V. cholerae has only been reported to cause sporadic cholera-like illness and localised outbreaks. The aim of this study was to determine the genetic diversity of non-O1/non-O139 V. cholerae isolates from hospitalised diarrhoeal patients in Zhejiang Province, China.
resultsIn an active surveillance of enteric pathogens in hospitalised diarrhoeal patients, nine non-O1/non-O139 V. cholerae isolates were identified from 746 diarrhoeal stool samples at a rate of 1.2%. These isolates and an additional 31 isolates from sporadic cases and three outbreaks were analysed using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). PFGE divided the isolates into 25 PFGE types while MLST divided them into 15 sequence types (STs). A single ST, ST80, was predominant which persisted over several years in different cities and caused two outbreaks in recent years. Antibiotic resistance varied with the majority of the isolates resistant to sulphamethoxazole/trimethoprim and nearly all isolates either resistant or intermediate to erythromycin and rifampicin. None of the isolates carried the cholera toxin genes or toxin co-regulated pilus genes but the majority carried a type III secretion system as the key virulence factor.
conclusionsNon-O1/non-O139 V. cholerae is an important contributor to diarrhoeal infections in China. Resistance to commonly used antibiotics limits treatment options. Continuous surveillance of non-O1/non-O139 V. cholerae is important for control and prevention of diarrhoeal infections.
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