ArticleBMC biochemistry2013
Nedd8 processing enzymes in Schizosaccharomyces pombe.
Article in BMC biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Characterization of Plasmodium falciparum NEDD8 and identification of cullins as its substrates.Scientific reports · 2020Article
- The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.Redox biology · 2020Review
- Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.PLoS pathogens · 2019Article
- The NEDD8 modification pathway in plants.Frontiers in plant science · 2014Review
- Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundConjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell cycle regulators. Like ubiquitin, Nedd8 is produced as a precursor that must first be processed before it becomes active. In Saccharomyces cerevisiae this is carried out exclusively by the enzyme Yuh1.
resultsHere we show that in the fission yeast, Schizosaccharomyces pombe, the Yuh1 orthologue, Uch1, is not the sole Nedd8 processing enzyme. Instead it appears that deubiquitylating enzymes can efficiently process the Nedd8 precursor in vivo.
conclusionsSeveral enzymes contribute to Nedd8 precursor processing including a number of deubiquitylating enzymes.
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Registered trials
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