ArticleBMC infectious diseases2013
Nosocomial outbreak of the pandemic Influenza A (H1N1) 2009 in critical hematologic patients during seasonal influenza 2010-2011: detection of oseltamivir resistant variant viruses.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Traditional definition of healthcare-associated influenza underestimates cases associated with other healthcare exposures in a population-based surveillance system.Infection control and hospital epidemiology · 2023Article
- The direct and indirect effects of COVID-19 pandemic in a real-life hematological setting.Cancer reports (Hoboken, N.J.) · 2021Article
- Effectiveness of a Mobile-Based Influenza-Like Illness Surveillance System (FluMob) Among Health Care Workers: Longitudinal Study.JMIR mHealth and uHealth · 2020Article
- Risk factors for hospital-acquired influenza A and patient characteristics: a matched case-control study.BMC infectious diseases · 2020Article
- Article
- Whole-genome Sequencing Provides Data for Stratifying Infection Prevention and Control Management of Nosocomial Influenza A.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Nosocomial outbreak of influenza A H3N2 in an inpatient oncology unit related to health care workers presenting to work while ill.American journal of infection control · 2019Article
- Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B.Scientific reports · 2019Article
- Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology.GMS hygiene and infection control · 2018Article
- Assessing the reporting quality of influenza outbreaks in the community.Influenza and other respiratory viruses · 2017Article
- Contacts of healthcare workers, patients and visitors in general wards in Singapore.Epidemiology and infection · 2017Article
- Viral Pneumonia in Patients with Hematopoietic Cell Transplantation and Hematologic Malignancies.Clinics in chest medicine · 2017Review
- Genotyping Influenza Virus by Next-Generation Deep Sequencing in Clinical Specimens.Annals of laboratory medicine · 2016Article
- Article
- Can newly developed, rapid immunochromatographic antigen detection tests be reliably used for the laboratory diagnosis of influenza virus infections?Journal of clinical microbiology · 2015Article
- Dengue Virus Evolution under a Host-Targeted Antiviral.Journal of virology · 2015Article
- [Lessons learned from pandemic influenza severe cases since 2009].Le praticien en anesthesie reanimation · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pandemic influenza A (H1N1) 2009 (H1N1pdm09) virus infection caused illness and death among people worldwide, particularly in hematologic/oncologic patients because influenza infected individuals can shed virus for prolonged periods, thus increasing the chances for the development of drug-resistant strains such as oseltamivir-resistant (OST-r) variant.
methodsThe aim of our study was to retrospectively evaluate the clinical importance of OST-r variant in circulating strains of the pandemic H1N1pdm09 virus. By means of RT-PCR and Sanger sequencing we analysed the presence of OST-r variant in 76 H1N1pdm09 laboratory-confirmed cases, hospitalized at the hematologic/oncologic ward at Spedali Civili of Brescia -Italy.
resultsOut of 76 hospitalized hematologic/oncologic patients, 23 patients (30.2%) were infected by H1N1pdm09 virus. Further investigation revealed that 3 patients were positive for the OST-r variant carrying the H275Y mutation. All the 23 infected patients were immuno-compromised, and were under treatment or had been treated previously with oseltamivir. Three patients died (13%) after admission to intensive care unit and only one of them developed H275Y mutation.
conclusionsOur retrospective observational study shows that pandemic influenza A (H1N1) 2009 virus can cause significant morbidity and even mortality in hematologic/oncologic patients and confirms the high rate of nosocomial transmission of pandemic H1N1pdm09 virus in these critical subjects. Indeed, the reduction in host defences in these hospitalized patients favoured the prolonged use of antiviral therapy and permitted the development of OST-r strain. Strategies as diagnostic vigilance, early isolation of patients and seasonal influenza A(H1N1) vaccination may prevent transmission of influenza in high risk individuals.
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