Evidence map›Paper›PMID 23496848›Full record

Trial reportNutrition journal2013

A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study.

Emily Oken, Lauren B Guthrie, Arienne Bloomingdale, Deborah N Platek, Sarah Price, Jess Haines, Matthew W Gillman, Sjurdur F Olsen, David C Bellinger, Robert O Wright

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrition journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01126762 (A Pilot Randomized Controlled Trial to Promote Healthful Fish Consumption in Pregnancy), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01126762 nacompletednot on this map

A Pilot Randomized Controlled Trial to Promote Healthful Fish Consumption in Pregnancy

TypeinterventionalSponsorHarvard Pilgrim Health CareRan2010 to 2011Enrolled61ConditionsNutritionArmsDietary advice, Control
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Fresh fish findings?The American journal of clinical nutrition · 2020
    Article
  11. Article
  12. Mercury, Polychlorinated Biphenyls, Selenium, and Fatty Acids in Tribal Fish Harvests of the Upper Great Lakes.Risk analysis : an official publication of the Society for Risk Analysis · 2018
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Cohort profile: project viva.International journal of epidemiology · 2015
    Observational
  19. Recruitment and retention of pregnant women into clinical research trials: an overview of challenges, facilitators, and best practices.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Emily OkenDepartment of Population Medicine, Harvard Medical School and the Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, Boston, MA 02215, USA. emily_oken@hphc.org
Lauren B Guthrie
Arienne Bloomingdale
Deborah N Platek
Sarah Price
Jess Haines
Matthew W Gillman
Sjurdur F Olsen
David C Bellinger
Robert O Wright
Harvard Pilgrim Health Care · USHarvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USHarvard Vanguard Medical Associates · USStatens Serum Institut · DK

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Superfund Metal Mixtures, Biomarkers and NeurodevelopmentP42ES016454 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BELLINGER, DAVID C · 2010 to 2015
$10.1M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
Environment, Fetal Tissue DNA Methylation & BirthweightR01ES020268 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2011 to 2013
$2.5M
Effects of prenatal diet and mercury exposure on child behavior and developmentR01ES016314 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2008 to 2011
$1.4M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
NICHD NIH HHS K24 HD069408NIDDK NIH HHS P30 DK040561NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01ES016314
6 · The paper itself

Abstract

backgroundNutritionists advise pregnant women to eat fish to obtain adequate docosahexaenoic acid (DHA), an essential nutrient important for optimal brain development. However, concern exists that this advice will lead to excess intake of methylmercury, a developmental neurotoxicant.

objectiveConduct a pilot intervention to increase consumption of high-DHA, low-mercury fish in pregnancy.

methodsIn April-October 2010 we recruited 61 women in the greater Boston, MA area at 12-22 weeks gestation who consumed <=2 fish servings/month, and obtained outcome data from 55. We randomized participants to 3 arms: Advice to consume low-mercury/high-DHA fish (n=18); Advice + grocery store gift cards (GC) to purchase fish (n=17); or Control messages (n=20). At baseline and 12-week follow-up we estimated intake of fish, DHA and mercury using a 1-month fish intake food frequency questionnaire, and measured plasma DHA and blood and hair total mercury.

resultsBaseline characteristics and mean (range) intakes of fish [21 (0-125) g/day] and DHA from fish [91 (0-554) mg/d] were similar in all 3 arms. From baseline to follow-up, intake of fish [Advice: 12 g/day (95% CI: -5, 29), Advice+GC: 22 g/day (5, 39)] and DHA [Advice: 70 mg/d (3, 137), Advice+GC: 161 mg/d (93, 229)] increased in both intervention groups, compared with controls. At follow-up, no control women consumed >= 200mg/d of DHA from fish, compared with 33% in the Advice arm (p=0.005) and 53% in the Advice+GC arm (p=0.0002). We did not detect any differences in mercury intake or in biomarker levels of mercury and DHA between groups.

conclusionsAn educational intervention increased consumption of fish and DHA but not mercury. Future studies are needed to determine intervention effects on pregnancy and childhood health outcomes.

trial registrationRegistered on clinicaltrials.gov as NCT01126762.

Indexed as

FishesAdultAnimalsBiomarkersBostonDocosahexaenoic AcidsFemaleFollow-Up StudiesFood ContaminationHumansMethylmercury CompoundsPilot ProjectsPregnancyPregnancy OutcomeSocioeconomic FactorsSurveys and QuestionnairesBiomarkersDocosahexaenoic AcidsMethylmercury Compounds

Identifiers

PMID23496848
PMCPMC3616846
OpenAlexW2123445485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.