ArticleBMC cancer2013
Is the prediction of prognosis not improved by the seventh edition of the TNM classification for colorectal cancer? Analysis of the surveillance, epidemiology, and end results (SEER) database.
Article in BMC cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- The prognostic significance of metastasis to No. 253 lymph node in stage III rectal cancer based on a bicenter retrospective study.Scientific reports · 2026Article
- E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway.European journal of histochemistry : EJH · 2025Article
- Narrative review of neoadjuvant therapy in patients with locally advanced colon cancer.The Kaohsiung journal of medical sciences · 2025Review
- Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023-2038.BMC cancer · 2024Article
- The Clinical Characteristics of a Stage II Colorectal Cancer T4 Tumor: A Ten-Year Single-Center Research Report.Current oncology (Toronto, Ont.) · 2024Article
- Does Adjuvant Chemotherapy Benefit Patients with T4 N0 Colon Cancer?Medicina (Kaunas, Lithuania) · 2024Article
- Construction and validation of artificial intelligence pathomics models for predicting pathological staging in colorectal cancer: Using multimodal data and clinical variables.Cancer medicine · 2024Observational
- The utility of surveillance CT scans in a cohort of survivors of colorectal cancer.Journal of cancer survivorship : research and practice · 2023Article
- Review
- Surgery for T4 Colorectal Cancer in Older Patients: Determinants of Outcomes.Journal of personalized medicine · 2022Article
- Tumor Stroma Ratio and Its Significance in Locally Advanced Colorectal Cancer.Current oncology (Toronto, Ont.) · 2022Review
- Beyond N staging in colorectal cancer: Current approaches and future perspectives.Frontiers in oncology · 2022Review
- Prognostic Factors Affecting Disease-Free Survival and Overall Survival in T4 Colon Cancer.Annals of coloproctology · 2021Article
- Article
- Proposal of a modified subclassification system for stage III colorectal cancer: A multi-institutional retrospective analysis.Annals of gastroenterological surgery · 2020Article
- ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX-based neoadjuvant concurrent chemoradiation.Oncology letters · 2020Article
- Surgical management and hyperthermic intraperitoneal chemotherapy for locally advanced colorectal cancer.Journal of gastrointestinal oncology · 2020Review
- An Immunoscore System Based On CD3OncoTargets and therapy · 2019Article
- Prognosis Prediction of Colorectal Cancer Using Gene Expression Profiles.Frontiers in oncology · 2019Article
- Significance of lymph node metastasis in the survival of stage IV colorectal cancer by hematogenous metastasis.Annals of surgical treatment and research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether the 7th edition of American Joint Committee on Cancer (AJCC) TNM staging system (AJCC-7) is a successful revision remains debatable. We aimed to compare the predictive capacity of the AJCC-7 for colorectal cancer with the 6th edition of the AJCC TNM staging system (AJCC-6).
methodsThe National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) dataset consisting of 158,483 records was used in this study. We evaluated the predictive capacity of the two editions of the staging system using Harrell's C index and Bayesian Information Criterion (BIC).
resultsThere was a significant prognostic difference between patients at stage IIB and IIC (P < 0.001). Stage III patients with similar prognoses were adequately sub-grouped in the same stage according to AJCC-7. The Harrell's C index revealed a value of 0.7692 for AJCC-7, which was significantly better than 0.7663 for AJCC-6 (P < 0.001). BIC analysis provided consistent results (P < 0.001).
conclusionsThis study demonstrates that AJCC-7 is superior to the AJCC-6 staging system in predictive capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.