ArticleRespiratory research2013
Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils.
Article in Respiratory research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Microbial biomarker development for detection and prognosis of early-stage non-small cell lung cancer.Cancer biomarkers : section A of Disease markers · 2025Review
- Related Risk Factors That Predict Moderate to Severe Asthma Attack in Children: Analysis Based on Logistic Regression and Decision Tree.International journal of general medicine · 2025Article
- Correlation Between mRNA Expression of Activated Eosinophils and Air Pollutant Exposure in Patients With Asthma.Immunity, inflammation and disease · 2024Article
- Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis.Frontiers in immunology · 2024Review
- Development of Adaptive Immunity and Its Role in Lung Remodeling.Advances in experimental medicine and biology · 2023Article
- Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives.Frontiers in allergy · 2022Review
- 1,25OH-Vitamin D3 and IL-17 Inhibition Modulate Pro-Fibrotic Cytokines Production in Peripheral Blood Mononuclear Cells of Patients with Systemic Sclerosis.International journal of medical sciences · 2022Article
- Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway.Experimental & molecular medicine · 2020Review
- In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-International journal of molecular sciences · 2020Article
- Interleukin-17 pathways in systemic sclerosis-associated fibrosis.Rheumatology international · 2019Review
- Interleukin-16 aggravates ovalbumin-induced allergic inflammation by enhancing Th2 and Th17 cytokine production in a mouse model.Immunology · 2019Article
- The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis.American journal of clinical dermatology · 2018Review
- IL-17 in the lung: the good, the bad, and the ugly.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment.Molecular cancer therapeutics · 2017Article
- Effects of Anti-IL-17 on Inflammation, Remodeling, and Oxidative Stress in an Experimental Model of Asthma Exacerbated by LPS.Frontiers in immunology · 2017Article
- Loss of CCR2 signaling alters leukocyte recruitment and exacerbates γ-herpesvirus-induced pneumonitis and fibrosis following bone marrow transplantation.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Relationship Between Serum Interleukin-17F Level and Severity of Atopic Dermatitis in Children.Pediatric allergy, immunology, and pulmonology · 2015Article
- Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A.PloS one · 2015Article
- Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies.World journal of gastroenterology · 2014Review
- Fish oil has beneficial effects on allergen-induced airway inflammation and hyperreactivity in mice.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma. Eosinophils have been shown to contribute to the production of pro-fibrotic cytokines, TGF-β and IL-11, however, the mechanism regulating this process is not fully understood.
objectiveIn this report, we investigated whether cytokines associated with inflammation during asthma may induce eosinophils to produce pro-fibrotic cytokines.
methodsEosinophils were isolated from peripheral blood of 10 asthmatics and 10 normal control subjects. Eosinophils were stimulated with Th1, Th2 and Th17 cytokines and the production of TGF-β and IL-11 was determined using real time PCR and ELISA assays.
resultsThe basal expression levels of eosinophil derived TGF-β and IL-11 cytokines were comparable between asthmatic and healthy individuals. Stimulating eosinophils with Th1 and Th2 cytokines did not induce expression of pro-fibrotic cytokines. However, stimulating eosinophils with Th17 cytokines resulted in the enhancement of TGF-β and IL-11 expression in asthmatic but not healthy individuals. This effect of IL-17 on eosinophils was dependent on p38 MAPK activation as inhibiting the phosphorylation of p38 MAPK, but not other kinases, inhibited IL-17 induced pro-fibrotic cytokine release.
conclusionsTh17 cytokines might contribute to airway fibrosis during asthma by enhancing production of eosinophil derived pro-fibrotic cytokines. Preventing the release of pro-fibrotic cytokines by blocking the effect of Th17 cytokines on eosinophils may prove to be beneficial in controlling fibrosis for disorders with IL-17 driven inflammation such as allergic and autoimmune diseases.
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