ArticleMolecular ecology2013
RAD-Seq derived markers flank the shell colour and banding loci of the Cepaea nemoralis supergene.
Article in Molecular ecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 90 citations in OpenAlex.
- Crossing experiments suggest a simple genetic basis of complex male self-sacrifice phenotypes in widow spiders.Biology letters · 2026Article
- Shell colour luminance of Cuban painted snails, Polymita picta and Polymita muscarum (Gastropoda: Cepolidae).PloS one · 2025Article
- High heteroplasmy is associated with low mitochondrial copy number and selection against non-synonymous mutations in the snail Cepaea nemoralis.BMC genomics · 2024Article
- Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map.Heredity · 2023Article
- Identifying genes associated with genetic control of color polymorphism in the pearl oysterEvolutionary applications · 2023Article
- Deep structure, long-distance migration and admixture in the colour polymorphic land snail Cepaea nemoralis.Journal of evolutionary biology · 2022Article
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- Quantitative measures and 3D shell models reveal interactions between bands and their position on growing snail shells.Ecology and evolution · 2021Article
- Whole-genome re-sequencing data to infer historical demography and speciation processes in land snails: the study of twoPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The draft genome sequence of the grove snail Cepaea nemoralis.G3 (Bethesda, Md.) · 2021Article
- Discrete or indiscrete? Redefining the colour polymorphism of the land snail Cepaea nemoralis.Heredity · 2019Article
- Recombination within the Cepaea nemoralis supergene is confounded by incomplete penetrance and epistasis.Heredity · 2019Article
- Morphometric and genetic differentiation among populations of flat-headed cusimanse (Ecology and evolution · 2018Article
- Identification and validation of reference genes for qPCR in the terrestrial gastropod Cepaea nemoralis.PloS one · 2018Article
- Colorful seashells: Identification of haem pathway genes associated with the synthesis of porphyrin shell color in marine snails.Ecology and evolution · 2017Article
- Reconstructed historical distribution and phylogeography unravels non-steppic origin ofOrganisms, diversity & evolution · 2017Article
- Development of a Medium Density Combined-Species SNP Array for Pacific and European Oysters (G3 (Bethesda, Md.) · 2017Article
- Genomics of coloration in natural animal populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- What explains rare and conspicuous colours in a snail? A test of time-series data against models of drift, migration or selection.Heredity · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Studies on the classic shell colour and banding polymorphism of the land snail Cepaea played a crucial role in establishing the importance of natural selection in maintaining morphological variation. Cepaea is also a pre-eminent model for ecological genetics because the outward colour and banding phenotype is entirely genetically determined, primarily by a 'supergene' of at least five loci. Unfortunately, progress in understanding the evolution and maintenance of the Cepaea polymorphism stalled, partly because of a lack of genetic markers. With a view to re-establish Cepaea as a prominent model of molecular ecology, we made six laboratory crosses of Cepaea nemoralis, five of which segregated for shell ground colour (C) and the presence or absence of bands (B). First, scoring of colour and banding in 323 individuals found no recombination between the C and B loci of the supergene. Second, using restriction site-associated DNA sequencing (RAD-Seq) of two parents and 22 offspring, we identified 44 anonymous markers putatively linked to the colour (C) and banding (B) loci. The genotype of eleven of the most promising RAD-Seq markers was independently validated in the same 22 offspring, then up to a further 146 offspring were genotyped. The closest RAD-Seq markers scored are within ~0.6 centimorgan (cM) of the C-B supergene linkage group, with the combined loci together forming a 35.8 cM linkage map of markers that flank both sides of the Cepaea C-B supergene.
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