ArticleAddiction biology2014
Age-related differences in working memory deficits during nicotine withdrawal.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies.Biological psychiatry · 2015Pooled it
- Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- Phase IIb Trial of an α7 Nicotinic Receptor Partial Agonist With and Without Nicotine Patch for Withdrawal-Associated Cognitive Deficits and Tobacco Abstinence.Journal of clinical psychopharmacology · 2018Trial
- Nicotine withdrawal alters neural responses to psychosocial stress.Psychopharmacology · 2016Trial
- Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study.Drug and alcohol dependence · 2013Trial
- Trial
- The effect of e-cigarettes on cognitive function: a scoping review.Psychopharmacology · 2024Article
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
- Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.Developmental cognitive neuroscience · 2018Review
- Nicotine Abstinence Influences the Calculation of Salience in Discrete Insular Circuits.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning.Neuropharmacology · 2017Article
- No Effect of Commercial Cognitive Training on Brain Activity, Choice Behavior, or Cognitive Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Withdrawal-Related Changes in Delay Discounting Predict Short-Term Smoking Abstinence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder.Frontiers in psychology · 2017Review
- Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure.The European journal of neuroscience · 2016Article
- Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate.Biological psychiatry · 2016Article
- The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function.Addiction biology · 2016Article
- Working memory-related neural activity predicts future smoking relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Verbal working memory in schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study: the moderating role of smoking status and antipsychotic medications.Schizophrenia research · 2015Article
- Cognitive deficits specific to depression-prone smokers during abstinence.Experimental and clinical psychopharmacology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three smokers participated in two blood oxygen level-dependent (BOLD) functional magnetic resonance imaging scans while performing a visual N-back task on two separate occasions: smoking as usual and after 24 hours of biochemically confirmed abstinence (order counterbalanced). Abstinence (versus smoking) led to reduced accuracy, slower median correct response time and reduced BOLD signal change in the three a priori regions of interest: medial frontal/cingulate gyrus and right and left dorsolateral prefrontal cortex. Significant age × session effects were found for BOLD signal change in all three regions, as well as for withdrawal and craving; for all measures, abstinence effects were attenuated in smokers aged ≥50 years compared with those <50 years old. These results suggest that abstinence effects on neurocognitive function may be more pronounced for younger smokers, and may indicate a new avenue for research exploring mechanisms underlying age differences in smoking cessation success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.