ReviewJournal of microscopy2013
Regulation of contact inhibition of locomotion by Eph-ephrin signalling.
Review in Journal of microscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Endodermal cells use contact inhibition of locomotion to achieve uniform cell dispersal during zebrafish gastrulation.iScience · 2025Article
- Inhibition of EphA2 by syndecan-4 in wounded skin regulates clustering of fibroblasts.Journal of molecular cell biology · 2025Article
- An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.Developmental cell · 2024Article
- Review
- Tumour follower cells: A novel driver of leader cells in collective invasion (Review).International journal of oncology · 2023Review
- The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells.Journal of experimental & clinical cancer research : CR · 2023Article
- Coordination of cell migration mediated by site-dependent cell-cell contact.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest.Developmental cell · 2018Article
- The effect of foxp3-overexpressing Treg cells on non-small cell lung cancer cells.Molecular medicine reports · 2018Article
- Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?International journal of molecular sciences · 2018Review
- Mechanisms and in vivo functions of contact inhibition of locomotion.Nature reviews. Molecular cell biology · 2017Review
- Molecular basis of contact inhibition of locomotion.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells.Molecular biology of the cell · 2015Article
- Rho GTPase signalling in cell migration.Current opinion in cell biology · 2015Review
- EphA receptors regulate prostate cancer cell dissemination through Vav2-RhoA mediated cell-cell repulsion.Biology open · 2014Article
- Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion.Development (Cambridge, England) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Contact inhibition of locomotion (CIL) occurs when a cell stops migrating in a particular direction upon contact with another cell. Many cancer cells show Contact inhibition of locomotion when contacting one another but display contact-unimpeded migration following collision with noncancer cells. Here we review current understanding of Contact inhibition of locomotion, from Abercrombie's historical studies of cells in tissue culture to more recent analyses of Contact inhibition of locomotion in vivo. We discuss the cellular machinery required for CIL and the molecular signals that regulate it. We focus on our recent finding that in prostate cancer cells, Contact inhibition of locomotion is regulated by a balance between EphA and EphB receptor signalling. We show that, as recently described for chick heart fibroblasts, microtubule dynamics are required for Contact inhibition of locomotion in prostate cancer cells and we propose that stabilization of microtubules could account for defective Contact inhibition of locomotion between cancer cells and noncancer cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.