Evidence map›Paper›PMID 23495188›Full record

ArticleAdvanced healthcare materials2013

μHall chip for sensitive detection of bacteria.

David Issadore, Hyun Jung Chung, Jaehoon Chung, Ghyslain Budin, Ralph Weissleder, Hakho Lee

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Nanotools for Sepsis Diagnosis and Treatment.Advanced healthcare materials · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Point-of-care rare cell cancer diagnostics.Methods in molecular biology (Clifton, N.J.) · 2015
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David IssadoreCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.
Hyun Jung Chung
Jaehoon Chung
Ghyslain Budin
Ralph Weissleder
Hakho Lee

Funding

Shape Memory Polymer Devices for Treating StrokeR01EB000462 · NIBIB · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI MAITLAND, DUNCAN J · 2002 to 2012
$12.5M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Magnetic nanoswitches for sensing biomoleculesR01EB004626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2004 to 2012
$3.2M
Novel Clickdyes for Biomedical SensingR01EB010011 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2010 to 2017
$3.1M
MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLESR01HL113156 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO · 2012 to 2016
$2.1M
NCI NIH HHS T32 CA079443NCI NIH HHS T32CA79443NHLBI NIH HHS R01 HL113156NHLBI NIH HHS R01-HL113156NIBIB NIH HHS R01 EB004626NIBIB NIH HHS R01- EB00462605A1NIBIB NIH HHS R01 EB010011NIBIB NIH HHS R01-EB010011
6 · The paper itself

Abstract

Sensitive, rapid and phenotype-specific enumeration of pathogens is essential for the diagnosis of infectious disease, monitoring of food chains, and for defense against bioterrorism. Microbiological culture and genotyping, techniques that sensitively and selectively detect bacteria in laboratory settings, have limited application in clinical environments due to high cost, slow response times, and the need for specially trained staff and laboratory infrastructure. To address these challenges, we developed a microfluidic chip-based micro-Hall (μHall) platform capable of measuring single, magnetically tagged bacteria directly in clinical specimens with minimal sample processing. We demonstrated the clinical utility of the μHall chip by enumerating Gram-positive bacteria. The overall detection limit of the system was similar to that of culture tests (~10 bacteria), but the assay time was 50-times faster. This low-cost, single-cell analytical technique is especially well-suited to diagnose infectious diseases in resource-limited clinical settings.

Indexed as

Anti-Bacterial AgentsBiosensing TechniquesCommunicable DiseasesCyclooctanesGenotypeGram-Positive BacteriaHumansMagnetite NanoparticlesMicrofluidic Analytical TechniquesVancomycinAnti-Bacterial AgentsCyclooctanesMagnetite NanoparticlesVancomycinbacterial detectionmagnetic nanoparticlesμHall

Identifiers

PMID23495188
PMCPMC4340655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.