ArticleThe open virology journal2013
HIV Infection Alters the Spectrum of HPV Subtypes Found in Cervical Smears and Carcinomas from Kenyan Women.
Article in The open virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
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The trial behind it
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Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Racial Disparities Associated with the Prevalence of Vaccine and Non-Vaccine HPV Types and Multiple HPV Infections between Asia and Africa: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Prevalence of high-risk HPV genotypes in sub-Saharan Africa according to HIV status: a 20-year systematic review.Epidemiology and health · 2021Pooled it
- Effect of HIV Infection on Human Papillomavirus Types Causing Invasive Cervical Cancer in Africa.Journal of acquired immune deficiency syndromes (1999) · 2016Pooled it
- Epidemiology of HPV Genotypes among HIV Positive Women in Kenya: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Pooled it
- A Single-Arm, Proof-Of-Concept Trial of Lopimune (Lopinavir/Ritonavir) as a Treatment for HPV-Related Pre-Invasive Cervical Disease.PloS one · 2016Trial
- National human papillomavirus vaccination (GH_PV) programme: Ghana at a crossroads; is vaccine supply alone enough to ensure success?Frontiers in global women's health · 2025Article
- Prevalence and risk factors of human papilloma virus infection among women living with HIV, Egypt, a cross sectional study.BMC public health · 2024Article
- Characterization of HPV subtypes in invasive cervical cancer in Botswana patients using a pan-pathogen microarray technology.Tumour virus research · 2023Article
- Article
- Prevalence of Human Papillomavirus (HPV) Genotypes in Cervicovaginal Secretions of Human Immunodeficiency Virus (HIV) Positive Indian Women and Correlation With Clinico-Virological Parameters.Frontiers in reproductive health · 2021Article
- Review
- Mapping the Current and Future Noncommunicable Disease Burden in Kenya by Human Immunodeficiency Virus Status: A Modeling Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Detection of types of HPV among HIV-infected and HIV-uninfected Kenyan women undergoing cryotherapy or loop electrosurgical excision procedure.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2020Observational
- Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.Nature genetics · 2020Article
- Human papillomavirus genotype profiles and cytological grades interlinkages in coinfection with HIV.The Pan African medical journal · 2020Article
- How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa.Frontiers in cellular and infection microbiology · 2020Review
- Characteristics of carcinogenic HPV genotypes in North China Plain and the association with cervical lesions.Medicine · 2019Article
- Community-based self-collected human papillomavirus screening in rural Zimbabwe.BMC public health · 2019Article
- Human papillomavirus correlates of high grade cervical dysplasia among HIV-Infected women at a major treatment centre in Nigeria: a cross-sectional study.The Pan African medical journal · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with high risk HPV is implicated in pre-cancerous squamous intraepithelial lesions and their progression to cervical cancer. In the developed countries, infection with HPV 16 and 18 accounts for ~70% of cervical cancers, but it has been established that HPV type prevalence differs according to worldwide geographical location. In sub Saharan Africa infection with HPV is known to be augmented by HIV, which is endemic in this region. It is not yet clear, however, whether this ultimately influences progression to cervical cancer. Papillocheck(TM) and multiplex PCR were used to determine the range of HPV genotypes found in cervical smears and carcinomas from HIV positive and negative Kenyan women. Smear samples from HIV-positive women had a higher prevalence of: multiple HPV infections; high-risk HPVs 52, 58, 68, potential high risk 53/70, low-risk 44/55 and abnormal cytology compared to HIV-negative women. A low overall prevalence (~8%) of types 16/18 was found in all smear samples tested (n = 224) although this increased in invasive cervical carcinoma tissues to ~80% for HIV-negative and ~46% for HIV-positive women. Furthermore, HPV45 was more common in cervical carcinoma tissues from HIV-positive women. In summary HIV infection appears to alter the spectrum of HPV types found in both cervical smears and invasive cervical carcinomas. It is hypothesised there could be a complex interplay between these viruses which could either positively or negatively influence the rate of progression to cervical cancer.
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Registered trials
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