Evidence map›Paper›PMID 23494615›Full record

Trial reportAnnals of neurology2013

Brain-machine interface in chronic stroke rehabilitation: a controlled study.

Ander Ramos-Murguialday, Doris Broetz, Massimiliano Rea, Leonhard Läer, Ozge Yilmaz, Fabricio L Brasil, Giulia Liberati, Marco R Curado, Eliana Garcia-Cossio, Alexandros Vyziotis and 7 more

7 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 390 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
390citing papers in PubMed, 17 pooled it
32.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03994042 nacompletednot on this mapstarted 2019, after this paper: background citation

EEG-based Mental Imagery Feedback in Stroke Patients With Severe Hand Dysfunction

TypeinterventionalSponsorMälardalen UniversityRan2019 to 2020Enrolled2ConditionsStroke, HemiparesisArmsMental imagery neurofeedback training
NCT04188132 naunknown statusnot on this mapstarted 2019, after this paper: background citation

EEG Based Brain Computer Interface in Chronic Stroke Survivors for Upper Limb Rehabilitation- A Pilot Study Using Motor Execution and Motor Imagery

TypeinterventionalSponsorUniversity of HoustonRan2019 to 2020Enrolled10ConditionsStroke Sequelae, Brain IschemiaArmsEEG -BCI based Feedback for rehabilitation
NCT04353297 nacompletednot on this mapstarted 2021, after this paper: background citation

The PROMOTOER: a BCI -Based Intervention That Promotes Upper Limb Functional Motor Recovery. A Randomized Clinical Trial to Test Long-term Efficacy and to Identify Determinants of Response to Intervention in Subacute Stroke Patients

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2021 to 2023Enrolled49ConditionsStroke, Motor DisordersArmsEEG-based BCI system for (hand) Motor Imagery training, Motor Imagery training
NCT04704427 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Rehabilitative BCI for Lower Limb Function Recovery in Acute Ischemic Stroke

TypeinterventionalSponsorXuanwu Hospital, BeijingRan2021 to 2021Enrolled40ConditionsStroke, AcuteArmsNon-invasive BCI training, Traditional Physiotherapy protocol
NCT05345301 nacompletednot on this mapstarted 2022, after this paper: background citation

Electroencephalographic Correlates of Glove-stretch Therapy Post-stroke

TypeinterventionalSponsorShirley Ryan AbilityLabRan2022 to 2022Enrolled10ConditionsStrokeArmsEvent related desynchronization measurement
NCT06409754 narecruitingnot on this mapstarted 2024, after this paper: background citation

Application of Functional Electrical Stimulation Therapy Coupled to a P300-based Brain-Computer Interface for Paretic Upper Limb Rehabilitation in Chronic Stroke: A Randomized Controlled Trial

TypeinterventionalSponsorInstituto Nacional de RehabilitacionRan2024 to 2026Enrolled26ConditionsStroke, Upper Extremity Paresis, Neuronal PlasticityArmsFunctional Electrical Stimulation Therapy coupled to a P-300 based Brain-Computer Interface, Conventional Physical Therapy
NCT06729658 early_phase1completednot on this mapstarted 2017, after this paper: background citation

The Effect of Dopaminergic Modulation on Brain Computer Interface Efficacy

TypeinterventionalSponsorMax Planck Institute for Human Cognitive and Brain SciencesRan2017 to 2024Enrolled22ConditionsHealthy ParticipantsArmsMadopar, Placebo
3 · Its place in the literature

Who cites it

390 citing papers in PubMed, 17 syntheses or guidelines pooled it, 965 citations in OpenAlex.

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  9. Efficacy of rTMS in treating functional impairment in post-stroke patients: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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330 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Ander Ramos-MurguialdayInstitute of Medical Psychology and Behavioral Neurobiology and Magnetoencephalography Center, University of Tübingen, Tübingen, Germany; Health Technologies Department, Tecnalia, San Sebastian, Spain.
Doris Broetz
Massimiliano Rea
Leonhard Läer
Ozge Yilmaz
Fabricio L Brasil
Giulia Liberati
Marco R Curado
Eliana Garcia-Cossio
Alexandros Vyziotis
Woosang Cho
Manuel Agostini
Ernesto Soares
Surjo Soekadar
Andrea Caria
Leonardo G Cohen
Niels Birbaumer
University of Tübingen · DENational Institute of Neurological Disorders and Stroke · USTecnalia · ES

Funding

Cortical reorganization and plasticity In the Healthy BrainZIANS002978 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$38.0M
Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Intramural NIH HHS ZIA NS003030
6 · The paper itself

Abstract

objectiveChronic stroke patients with severe hand weakness respond poorly to rehabilitation efforts. Here, we evaluated efficacy of daily brain-machine interface (BMI) training to increase the hypothesized beneficial effects of physiotherapy alone in patients with severe paresis in a double-blind sham-controlled design proof of concept study.

methodsThirty-two chronic stroke patients with severe hand weakness were randomly assigned to 2 matched groups and participated in 17.8 ± 1.4 days of training rewarding desynchronization of ipsilesional oscillatory sensorimotor rhythms with contingent online movements of hand and arm orthoses (experimental group, n = 16). In the control group (sham group, n = 16), movements of the orthoses occurred randomly. Both groups received identical behavioral physiotherapy immediately following BMI training or the control intervention. Upper limb motor function scores, electromyography from arm and hand muscles, placebo-expectancy effects, and functional magnetic resonance imaging (fMRI) blood oxygenation level-dependent activity were assessed before and after intervention.

resultsA significant group × time interaction in upper limb (combined hand and modified arm) Fugl-Meyer assessment (cFMA) motor scores was found. cFMA scores improved more in the experimental than in the control group, presenting a significant improvement of cFMA scores (3.41 ± 0.563-point difference, p = 0.018) reflecting a clinically meaningful change from no activity to some in paretic muscles. cFMA improvements in the experimental group correlated with changes in fMRI laterality index and with paretic hand electromyography activity. Placebo-expectancy scores were comparable for both groups.

interpretationThe addition of BMI training to behaviorally oriented physiotherapy can be used to induce functional improvements in motor function in chronic stroke patients without residual finger movements and may open a new door in stroke neurorehabilitation.

Indexed as

Brain-Computer InterfacesStroke RehabilitationAdolescentAdultAgedAged, 80 and overAnalysis of VarianceArmBrainBrain WavesCase-Control StudiesChronic DiseaseElectroencephalographyElectromyographyFemaleHand

Identifiers

PMID23494615
PMCPMC3700597
OpenAlexW2133561518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.