ArticleTransgenic research2013
Generation of mice encoding a conditional allele of Nkx2.2.
Article in Transgenic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Molecularly distinct subtypes ofiScience · 2026Article
- NKX2.2 and KLF4 cooperate to regulate α-cell identity.Genes & development · 2025Article
- Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2.2.Molecular neurobiology · 2023Article
- NK2 homeobox gene cluster: Functions and roles in human diseases.Genes & diseases · 2023Review
- Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury.International journal of molecular sciences · 2023Article
- Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain.Genes & development · 2023Article
- Groucho co-repressor proteins regulate β cell development and proliferation by repressingDevelopment (Cambridge, England) · 2021Article
- Evidence ThatFrontiers in cellular neuroscience · 2021Article
- Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Genetic Lineage Tracing in Taste Tissues Using Sox2-CreERT2 Strain.Chemical senses · 2017Article
- Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo.Scientific reports · 2017Article
- Article
- Pancreatic β cell identity requires continual repression of non-β cell programs.The Journal of clinical investigation · 2017Article
- Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function.Endocrinology · 2017Article
- The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.Development (Cambridge, England) · 2016Article
- βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.Genes & development · 2016Article
- Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination.Neuroscience · 2015Article
- The new CRISPR-Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals.Transgenic research · 2014Review
- Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.Development (Cambridge, England) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nkx2.2 is a homeobox transcription factor that is expressed in the pancreas, intestine and central nervous system (CNS) during embryogenesis and in the adult. In mice, global deletion of Nkx2.2 results in cell mis-specification in each of the tissues where it is expressed, and the null mice die as neonates with severe hyperglycemia. Although a whole body knockout demonstrates the importance of Nkx2.2 in cell specification and postnatal viability, it precludes assessment of the cell-autonomous and postnatal functions of Nkx2.2. In this study we report the generation and functional characterization of mice encoding a conditional allele of Nkx2.2. We demonstrate the functional integrity of the conditional Nkx2.2 allele and report successful in vivo deletion using a pancreas-specific Cre recombinase. The pancreas-specific deletion of Nkx2.2 results in similar defects found in the Nkx2.2 null pancreas and the mice die shortly after birth, demonstrating that the neonatal lethality associated with the null allele is caused by pancreatic islet dysfunction. The generation of a conditional Nkx2.2 allele provides an important tool for identifying the cell-autonomous and postnatal activities of Nkx2.2 in establishing and maintaining cell type identities and functions in the pancreas, intestine and CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.