ArticleIranian journal of basic medical sciences2012
The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients.
Article in Iranian journal of basic medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Progress of the pathogenesis in varicocele: a narrative review.The Canadian journal of urology · 2026Review
- Review
- Genetics and epigenetics of varicocele pathophysiology: an overview.Journal of assisted reproduction and genetics · 2017Review
- The POLG Polyglutamine Tract Variants in Iranian Patients with Multiple Sclerosis.Iranian journal of child neurology · 2015Article
- Mutation analysis of TNP1 gene in infertile men with varicocele.Iranian journal of reproductive medicine · 2014Article
- No association between single nucleotide polymorphisms in pre-mirnas and the risk of gastric cancer in Chinese population.Iranian journal of basic medical sciences · 2014Article
- Significance of microRNA targeted estrogen receptor in male fertility.Iranian journal of basic medical sciences · 2014Article
- Mitochondrial DNA polymerase gamma gene polymorphism is not associated with male infertility.Journal of assisted reproduction and genetics · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVaricocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients. MATERIALS AND
methodsWe determined the POLG CAG repeat length in DNA samples extracted from 40 varicocele patients and 30 control subjects by PCR-denature polyacrylamide gel electrophoresis and sequencing.
resultsThe distribution of the CAG repeat length in varicocele patients showed no notable difference from that in control subjects, but we found a significant statistical inverse correlation between 10/10 and 10/#10 genotypes and varicocele grade.
conclusionThese findings indicate that POLG CAG repeats may affects the varicocele grade, but the mechanisms remain to be elucidated.
Indexed as
Identifiers
23493802PMC3586882W2187986927What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.