Evidence map›Paper›PMID 23493660›Full record

ArticleJournal of biomaterials and tissue engineering2012

Rat Cortical Oligodendrocyte-Embryonic Motoneuron Co-Culture: An

Hedvika Davis, Mercedes Gonzalez, Neelima Bhargava, Maria Stancescu, James J Hickman, Stephen Lambert

Open access · greenAbstract read
In one paragraph

Article in Journal of biomaterials and tissue engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Self-contained, low-cost Body-on-a-Chip systems for drug development.Experimental biology and medicine (Maywood, N.J.) · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hedvika DavisHybrid Systems Laboratory, NanoScience Technology Center, University of Central Florida, Orlando, FL 32826, USA ; College of Medicine, Biomedical Science Program, University of Central Florida, Orlando, FL 32826, USA.
Mercedes Gonzalez
Neelima Bhargava
Maria Stancescu
James J Hickman
Stephen Lambert
University of Central Florida · US

Funding

An In Vitro Model of Stem Cell Innervation of MyotubesR01NS050452 · NINDS · UNIVERSITY OF CENTRAL FLORIDA · PI HICKMAN, JAMES J · 2005 to 2020
$6.4M
Functional Invitro CNS and PNS Myelination ModelR01EB009429 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI LAMBERT, STEPHEN · 2010 to 2013
$1.7M
NIBIB NIH HHS R01 EB009429NINDS NIH HHS R01 NS050452
6 · The paper itself

Abstract

Mechanisms that control the differentiation and function of oligodendrocytes in the central nervous system are complex and involve multiple inputs from the surrounding environment, including localized concentrations of growth factors and the extracellular matrix. Dissection and analysis of these inputs are key to understanding the pathology of central nervous system demyelinating diseases such as multiple sclerosis, where the differentiation of myelinating oligodendrocytes from their precursors underlies the remission phase of the disease.

Indexed as

Co-CultureDETAIn VitroMBPMotoneuronsOligodendrocytesSerum-Free

Identifiers

PMID23493660
PMCPMC3593593
OpenAlexW1973157651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.